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    TMEM52B transmembrane protein 52B [ Homo sapiens (human) ]

    Gene ID: 120939, updated on 9-Dec-2024

    Summary

    Official Symbol
    TMEM52Bprovided by HGNC
    Official Full Name
    transmembrane protein 52Bprovided by HGNC
    Primary source
    HGNC:HGNC:26438
    See related
    Ensembl:ENSG00000165685 AllianceGenome:HGNC:26438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C12orf59
    Summary
    Located in extracellular exosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward kidney (RPKM 46.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TMEM52B in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10170513..10191804)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10057239..10078519)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10323112..10344403)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369655 Neighboring gene heterogeneous nuclear ribonucleoprotein A/B pseudogene 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:10286337-10287157 Neighboring gene C-type lectin domain containing 7A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:10305885-10306388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5959 Neighboring gene MPRA-validated peak1568 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:10331989-10333188 Neighboring gene oxidized low density lipoprotein receptor 1 Neighboring gene MPRA-validated peak1569 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4236 Neighboring gene GABARAPL1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:10364713-10365255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4237 Neighboring gene GABA type A receptor associated protein like 1 Neighboring gene killer cell lectin like receptor D1 Neighboring gene uncharacterized LOC124902875

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ31166, MGC111385

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079815.2NP_001073283.1  transmembrane protein 52B isoform 2 precursor

      See identical proteins and their annotated locations for NP_001073283.1

      Status: VALIDATED

      Source sequence(s)
      AC024224, AC115676
      Consensus CDS
      CCDS66314.1
      UniProtKB/Swiss-Prot
      Q4KMG9, Q96NA7
      Related
      ENSP00000371348.2, ENST00000381923.6
      Conserved Domains (1) summary
      pfam14979
      Location:31162
      TMEM52; Transmembrane 52
    2. NM_001384894.1NP_001371823.1  transmembrane protein 52B isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC024224, AC115676
      Consensus CDS
      CCDS66314.1
      UniProtKB/Swiss-Prot
      Q4KMG9, Q96NA7
      Conserved Domains (1) summary
      pfam14979
      Location:31162
      TMEM52; Transmembrane 52
    3. NM_001384895.1NP_001371824.1  transmembrane protein 52B isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC024224, AC115676
      Consensus CDS
      CCDS66314.1
      UniProtKB/Swiss-Prot
      Q4KMG9, Q96NA7
      Conserved Domains (1) summary
      pfam14979
      Location:31162
      TMEM52; Transmembrane 52
    4. NM_001384896.1NP_001371825.1  transmembrane protein 52B isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC115676
      Consensus CDS
      CCDS66314.1
      UniProtKB/Swiss-Prot
      Q4KMG9, Q96NA7
      Related
      ENSP00000445582.2, ENST00000543484.2
      Conserved Domains (1) summary
      pfam14979
      Location:31162
      TMEM52; Transmembrane 52
    5. NM_001384897.1NP_001371826.1  transmembrane protein 52B isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC115676
      Conserved Domains (1) summary
      pfam14979
      Location:34149
      TMEM52; Transmembrane 52
    6. NM_001384898.1NP_001371827.1  transmembrane protein 52B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC024224, AC115676
      Consensus CDS
      CCDS8619.1
      Conserved Domains (1) summary
      pfam14979
      Location:13142
      TMEM52; Transmembrane 52
    7. NM_153022.4NP_694567.1  transmembrane protein 52B isoform 1

      See identical proteins and their annotated locations for NP_694567.1

      Status: VALIDATED

      Source sequence(s)
      AC115676, AY358845, BE301029
      Consensus CDS
      CCDS8619.1
      UniProtKB/Swiss-Prot
      Q4KMG9
      Related
      ENSP00000298530.3, ENST00000298530.7
      Conserved Domains (1) summary
      pfam14979
      Location:13142
      TMEM52; Transmembrane 52

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      10170513..10191804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10057239..10078519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)