ZNF367 zinc finger protein 367 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF367provided by HGNC
Official Full Name: zinc finger protein 367provided by HGNC
Primary source: HGNC:HGNC:18320
See related: Ensembl:ENSG00000165244 MIM:610160; AllianceGenome:HGNC:18320
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AFF29; ZFF29; CDC14B
Summary: Enables DNA-binding transcription factor activity. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bone marrow (RPKM 8.1), testis (RPKM 3.6) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q22.32; 9q22.32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (96385941..96418370, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (108557662..108590090, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (99148223..99180652, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zinc finger protein 367 exerts a cancer-promoting role in small cell lung cancer by influencing the CIT/LATS2/YAP signaling cascade.
Title: Zinc finger protein 367 exerts a cancer-promoting role in small cell lung cancer by influencing the CIT/LATS2/YAP signaling cascade.
ZNF367-induced transcriptional activation of KIF15 accelerates the progression of breast cancer.
Title: ZNF367-induced transcriptional activation of KIF15 accelerates the progression of breast cancer.
Inhibition of zinc finger protein 367 exerts a tumor suppressive role in colorectal cancer by affecting the activation of oncogenic YAP1 signaling.
Title: Inhibition of zinc finger protein 367 exerts a tumor suppressive role in colorectal cancer by affecting the activation of oncogenic YAP1 signaling.
Validation of the OncoMasTR Risk Score in Estrogen Receptor-Positive/HER2-Negative Patients: A TransATAC study.
Title: Validation of the OncoMasTR Risk Score in Estrogen Receptor-Positive/HER2-Negative Patients: A TransATAC study.
Over-expression of MiR-24 could significantly promoted cell migration and invasion (p<0.05). ZNF367 was a downstream target of MiR-24 and down-regulated by MiR-24. Knockdown of ZNF367 remarkably promoted NSCLC cell proliferation (p<0.05).
Title: MiR-24 promotes migration and invasion of non-small cell lung cancer by targeting ZNF367.
ZNF367 is overexpressed in a variety of endocrine cancers and that it inhibits in vitro and in vivo growth, cellular invasion, migration, and adhesion. ZNF367 overexpression is associated with the loss of miR-195 expression.
Title: ZNF367 inhibits cancer progression and is targeted by miR-195.
molecular cloning of ZFF29 (zinc-finger protein of human fetal liver erythroid cells 29), from human fetal liver erythroid cells
Title: Molecular cloning and characterization of ZFF29: a protein containing a unique Cys2His2 zinc-finger motif.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 367

Names: C2H2 zinc finger protein ZFF29; C2H2 zinc finger protein ZFF29a; CDC14 cell division cycle 14 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153695.4 → NP_710162.1 zinc finger protein 367

See identical proteins and their annotated locations for NP_710162.1

Status: VALIDATED

Source sequence(s)

AK091289, AY554165, BX116676, DR000756

Consensus CDS

CCDS6718.1

UniProtKB/Swiss-Prot

Q6Q7C8, Q7RTV3

Related

ENSP00000364405.4, ENST00000375256.5

Conserved Domains (4) summary

COG5048
Location:167 → 240

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:169 → 189

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:168 → 189

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:181 → 208

zf-H2C2_2; Zinc-finger double domain