U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    LINC01123 long intergenic non-protein coding RNA 1123 [ Homo sapiens (human) ]

    Gene ID: 440894, updated on 10-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    LINC01123provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1123provided by HGNC
    Primary source
    HGNC:HGNC:49269
    See related
    Ensembl:ENSG00000204588 AllianceGenome:HGNC:49269
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in brain (RPKM 18.1), duodenum (RPKM 15.3) and 22 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LINC01123 in Genome Data Viewer
    Location:
    2q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (109986980..109995281)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (110409236..110417561)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (110744557..110752858)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene LIMS3-LOC440895 readthrough Neighboring gene two pore channel 3 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:110738405-110738906 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:110738907-110739406 Neighboring gene glycosylphosphatidylinositol anchor attachment 1 pseudogene 1 Neighboring gene zinc finger and BTB domain containing 45 pseudogene 1 Neighboring gene zinc finger protein 532 pseudogene Neighboring gene uncharacterized LOC112268438 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:110781467-110782104 Neighboring gene platelet endothelial aggregation receptor 1-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:110782940-110783824

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Long non-coding RNA LINC01123 promotes cell proliferation, migration and invasion via interacting with SRSF7 in colorectal cancer. Liu Z, et al. Pathol Res Pract, 2022 Apr. PMID 35325644
    2. Knockdown of LINC01123 inhibits cell viability, migration and invasion via miR-361-3p/TSPAN1 targeting in cervical cancer. Li C, et al. Exp Ther Med, 2021 Oct. PMID 34475974, Free PMC Article
    3. LINC01123 facilitates proliferation, invasion and chemoresistance of colon cancer cells. Ye S, et al. Biosci Rep, 2020 Aug 28. PMID 32700743, Free PMC Article
    4. LINC01123 is associated with prognosis of oral squamous cell carcinoma and involved in tumor progression by sponging miR-34a-5p. Qin H, et al. Oral Surg Oral Med Oral Pathol Oral Radiol, 2022 Jan. PMID 34511356
    5. ZEB1-activated LINC01123 accelerates the malignancy in lung adenocarcinoma through NOTCH signaling pathway. Zhang M, et al. Cell Death Dis, 2020 Nov 15. PMID 33191397, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC01123 acts as an oncogenic driver in lung adenocarcinoma by regulating the miR-4766-5p/PYCR1 axis.
      Title: LINC01123 acts as an oncogenic driver in lung adenocarcinoma by regulating the miR-4766-5p/PYCR1 axis.
    2. Long non-coding RNA LINC01123 promotes cell proliferation, migration and invasion via interacting with SRSF7 in colorectal cancer.
      Title: Long non-coding RNA LINC01123 promotes cell proliferation, migration and invasion via interacting with SRSF7 in colorectal cancer.
    3. LINC01123 promotes immune escape by sponging miR-214-3p to regulate B7-H3 in head and neck squamous-cell carcinoma.
      Title: LINC01123 promotes immune escape by sponging miR-214-3p to regulate B7-H3 in head and neck squamous-cell carcinoma.
    4. LINC01123 is associated with prognosis of oral squamous cell carcinoma and involved in tumor progression by sponging miR-34a-5p.
      Title: LINC01123 is associated with prognosis of oral squamous cell carcinoma and involved in tumor progression by sponging miR-34a-5p.
    5. LINC01123 potentially correlates with radioresistance in glioma through the miR-151a/CENPB axis.
      Title: LINC01123 potentially correlates with radioresistance in glioma through the miR-151a/CENPB axis.
    6. LINC01123 promotes cell proliferation and migration via regulating miR-1277-5p/KLF5 axis in ox-LDL-induced vascular smooth muscle cells.
      Title: LINC01123 promotes cell proliferation and migration via regulating miR-1277-5p/KLF5 axis in ox-LDL-induced vascular smooth muscle cells.
    7. LINC01123 enhances osteosarcoma cell growth by activating the Hedgehog pathway via the miR-516b-5p/Gli1 axis.
      Title: LINC01123 enhances osteosarcoma cell growth by activating the Hedgehog pathway via the miR-516b-5p/Gli1 axis.
    8. ZEB1-activated LINC01123 accelerates the malignancy in lung adenocarcinoma through NOTCH signaling pathway.
      Title: ZEB1-activated LINC01123 accelerates the malignancy in lung adenocarcinoma through NOTCH signaling pathway.
    9. LINC01123 facilitates proliferation, invasion and chemoresistance of colon cancer cells.
      Title: LINC01123 facilitates proliferation, invasion and chemoresistance of colon cancer cells.
    10. Functional assays showed that LINC01123 promoted NSCLC cell proliferation and aerobic glycolysis. Mechanistic investigations revealed that LINC01123 was a direct transcriptional target of c-Myc. LINC01123 increased c-Myc mRNA expression by sponging miR-199a-5p.
      Title: LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

    Go to the top of the page Help

    Markers

    Clone Names

    • AC013268.5

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_046110.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC013268, AK056084, BC101448, BP247062
      Related
      ENST00000419296.1

    2. NR_046111.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 3' exon, compared to variant 1.
      Source sequence(s)
      AC013268, AK056084, BC101448, BP247062

    3. NR_046112.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate internal exons, compared to variant 1.
      Source sequence(s)
      AC013268, AK056084, BP247062, DA999847

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      109986980..109995281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      110409236..110417561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials