Tac2 tachykinin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tac2provided by MGI
Official Full Name: tachykinin 2provided by MGI
Primary source: MGI:MGI:98476
See related: Ensembl:ENSMUSG00000025400 AllianceGenome:MGI:98476
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tac3; PPT-B
Summary: This gene encodes a member of the tachykinin family of signaling peptides that is widely expressed in the central nervous system and plays a role in diverse processes such as water homeostasis, pulmonary inflammation, cognition, fear memory consolidation and preeclampsia. The encoded protein is enzymatically processed to generate the mature neuropeptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression: Biased expression in liver E14.5 (RPKM 9.9), liver E14 (RPKM 8.0) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 74.81 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (127560347..127567637)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127724478..127731768)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function.
Title: The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function.
Developmental sex differences in the peri-pubertal pattern of hypothalamic reproductive gene expression, including Kiss1 and Tac2, may contribute to sex differences in puberty onset.
Title: Developmental sex differences in the peri-pubertal pattern of hypothalamic reproductive gene expression, including Kiss1 and Tac2, may contribute to sex differences in puberty onset.
Characterization of the Action of Tachykinin Signaling on Pulsatile LH Secretion in Male Mice.
Title: Characterization of the Action of Tachykinin Signaling on Pulsatile LH Secretion in Male Mice.
Sex differences in fear memory consolidation via Tac2 signaling in mice.
Title: Sex differences in fear memory consolidation via Tac2 signaling in mice.
gene expression in the hypothalamus did not significantly change after 90 or 180 min restraint stress
Title: Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice.
Incongruent pattern of neurokinin B expression in rat and mouse brains.
Title: Incongruent pattern of neurokinin B expression in rat and mouse brains.
Study in mice provide evidence for Tac2 as a strong candidate gene who likely plays a role in hippocampal stress processing and neural plasticity.
Title: Exploring the involvement of Tac2 in the mouse hippocampal stress response through gene networking.
steroidal environment and energy state negatively regulate kisspeptin (Kiss1), neurokinin B (Tac2), and dynorphin (Pdyn) gene expression.
Title: The interaction of fasting, caloric restriction, and diet-induced obesity with 17β-estradiol on the expression of KNDy neuropeptides and their receptors in the female mouse.
This study showed a new evidence that furthers our understanding for the mechanisms underlying Tac2-dependent cellular pathways in fear learning.
Title: Amygdala-Dependent Molecular Mechanisms of the Tac2 Pathway in Fear Learning.
Data show that estrogen receptor alpha (ERalpha) in tachykinin 2 protein (Tac2) neurons typically restrains pubertal onset and hypothalamic reproductive drive.
Title: ERα in Tac2 Neurons Regulates Puberty Onset in Female Mice.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tac2 (e-PCR), detects polymorphism
- UniSTS:525948

Tac2 (e-PCR), detects polymorphism
- UniSTS:144537

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuromedin K receptor binding	ISO Inferred from Sequence Orthology more info
enables substance K receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in tachykinin receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tachykinin-3

Names: neurokinin 2; neurokinin A; neurokinin B-like protein Zneurok1; neurokinin alpha; neuromedin L; neuropeptide K; preprotachykinin-B; substance K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199971.1 → NP_001186900.1 tachykinin-3 preproprotein

See identical proteins and their annotated locations for NP_001186900.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC160970, BC031348

Consensus CDS

CCDS24248.1

UniProtKB/Swiss-Prot

P55099, Q9QXS9

Related

ENSMUSP00000136622.2, ENSMUST00000179960.8

Conserved Domains (1) summary

pfam03823
Location:1 → 53

Neurokinin_B; Neurokinin B
NM_009312.2 → NP_033338.2 tachykinin-3 preproprotein

See identical proteins and their annotated locations for NP_033338.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC160970, BC031348

Consensus CDS

CCDS24248.1

UniProtKB/Swiss-Prot

P55099, Q9QXS9

Related

ENSMUSP00000026466.4, ENSMUST00000026466.5

Conserved Domains (1) summary

pfam03823
Location:1 → 53

Neurokinin_B; Neurokinin B