Id4 inhibitor of DNA binding 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Id4provided by MGI
Official Full Name: inhibitor of DNA binding 4provided by MGI
Primary source: MGI:MGI:99414
See related: Ensembl:ENSMUSG00000021379 AllianceGenome:MGI:99414
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Idb4; bHLHb27
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in circadian rhythm. Acts upstream of or within several processes, including gland morphogenesis; negative regulation of cell differentiation; and nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; immune system; sensory organ; and urinary system. Used to study osteoporosis. Orthologous to human ID4 (inhibitor of DNA binding 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 65.3), whole brain E14.5 (RPKM 62.6) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A5; 13 24.71 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (48414592..48419504)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (48261116..48266028)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression.
Title: Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression.
Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p.
Title: Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p.
miR-210-3p protects against osteoarthritis through inhibiting subchondral angiogenesis by targeting the expression of TGFBR1 and ID4.
Title: miR-210-3p protects against osteoarthritis through inhibiting subchondral angiogenesis by targeting the expression of TGFBR1 and ID4.
DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation.
Title: DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation.
Targeted Disruption of the Inhibitor of DNA Binding 4 (Id4) Gene Alters Photic Entrainment of the Circadian Clock.
Title: Targeted Disruption of the Inhibitor of DNA Binding 4 (Id4) Gene Alters Photic Entrainment of the Circadian Clock.
Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus.
Title: Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus.
Id4 is a transcriptional regulator critically involved in the differentiation of OPN-type osteoblasts. JNK-Id4 signaling axis is crucial in the control of OPN and OCN expression during osteoblastic differentiation.
Title: JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4).
Id4 and other Id proteins promote elimination of Ascl1 protein in neural stem cells culture. Id4 sequesters Ascl1 heterodimerization partner E47, promoting Ascl1 protein degradation and stem cell quiescence.
Title: Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells.
BMP9 prevents induction of osteopontin in JNK-inactivated osteoblasts via Hey1-Id4 interaction.
Title: BMP9 prevents induction of osteopontin in JNK-inactivated osteoblasts via Hey1-Id4 interaction.
ID4 has a role in stem cell or progenitor capacity in spermatogonia and dictates the interface of transition between the different functional states
Title: ID4 levels dictate the stem cell state in mouse spermatogonia.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Id4 (e-PCR), detects polymorphism
- UniSTS:546828

RH144051 (e-PCR)
- UniSTS:233297

PMC133998P7 (e-PCR)
- UniSTS:270712

Id4 (e-PCR), detects polymorphism
- UniSTS:502662

X75018 (e-PCR)
- UniSTS:125840

Idb4 (e-PCR), detects polymorphism
- UniSTS:256942

Idb4 (e-PCR), detects polymorphism
- UniSTS:256475

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription regulator inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of astrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of astrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within prostate gland epithelium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prostate gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within prostate gland stromal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seminal vesicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA-binding protein inhibitor ID-4

Names: inhibitor of differentiation 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031166.3 → NP_112443.1 DNA-binding protein inhibitor ID-4

Status: VALIDATED

Source sequence(s)

AC123857

Consensus CDS

CCDS26492.1

UniProtKB/Swiss-Prot

P41139

UniProtKB/TrEMBL

Q544D2

Related

ENSMUSP00000021810.2, ENSMUST00000021810.3

Conserved Domains (1) summary

cd19694
Location:62 → 117

bHLH_dnHLH_ID4; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID4 and similar proteins