Taf12 TATA-box binding protein associated factor 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taf12provided by MGI
Official Full Name: TATA-box binding protein associated factor 12provided by MGI
Primary source: MGI:MGI:1913714
See related: Ensembl:ENSMUSG00000028899 AllianceGenome:MGI:1913714
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 20kDa; Taf2J; 2810422D08Rik
Summary: Enables DNA binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; mRNA transcription by RNA polymerase II; and positive regulation of transcription initiation by RNA polymerase II. Located in nucleus. Part of SAGA complex. Is expressed in early conceptus; limb; oocyte; and tail. Orthologous to human TAF12 (TATA-box binding protein associated factor 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 16.3), liver E14.5 (RPKM 13.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 65.09 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (132001667..132020640)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (132274355..132293329)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter-enhancer looping.
Title: The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter-enhancer looping.
ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD.
Title: Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
contributes_to RNA polymerase II general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables TBP-class protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	ISO Inferred from Sequence Orthology more info
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polymerase II preinitiation complex assembly	ISO Inferred from Sequence Orthology more info
involved_in RNA polymerase II preinitiation complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription initiation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of RNA splicing	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation at RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	ISO Inferred from Sequence Orthology more info
part_of SAGA complex	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of transcription factor TFIID complex	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription factor TFTC complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFTC complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: transcription initiation factor TFIID subunit 12

Names: TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20 kDa; TAFII-20; TAFII20; transcription initiation factor TFIID 20 kDa subunits

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025579.3 → NP_079855.2 transcription initiation factor TFIID subunit 12

See identical proteins and their annotated locations for NP_079855.2

Status: VALIDATED

Source sequence(s)

AK132927, AK139748, BE630738, BY069348

Consensus CDS

CCDS18721.1

UniProtKB/Swiss-Prot

Q3V0S7, Q8VE65, Q9CZ11, Q9D8Q0

UniProtKB/TrEMBL

Q3UT56

Related

ENSMUSP00000030731.5, ENSMUST00000030731.11

Conserved Domains (1) summary

cd07981
Location:58 → 126

TAF12; TATA Binding Protein (TBP) Associated Factor 12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

132001667..132020640

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539110.3 → XP_006539173.1 transcription initiation factor TFIID subunit 12 isoform X3

See identical proteins and their annotated locations for XP_006539173.1

UniProtKB/Swiss-Prot

Q3V0S7, Q8VE65, Q9CZ11, Q9D8Q0

UniProtKB/TrEMBL

Q3UT56

Conserved Domains (1) summary

cd07981
Location:58 → 126

TAF12; TATA Binding Protein (TBP) Associated Factor 12
XM_006539109.2 → XP_006539172.1 transcription initiation factor TFIID subunit 12 isoform X3

See identical proteins and their annotated locations for XP_006539172.1

UniProtKB/Swiss-Prot

Q3V0S7, Q8VE65, Q9CZ11, Q9D8Q0

UniProtKB/TrEMBL

Q3UT56

Conserved Domains (1) summary

cd07981
Location:58 → 126

TAF12; TATA Binding Protein (TBP) Associated Factor 12
XM_036164314.1 → XP_036020207.1 transcription initiation factor TFIID subunit 12 isoform X2

UniProtKB/TrEMBL

E9QNT5

Related

ENSMUSP00000101583.2, ENSMUST00000105963.2

Conserved Domains (1) summary

cd07981
Location:110 → 178

TAF12; TATA Binding Protein (TBP) Associated Factor 12
XM_017320350.2 → XP_017175839.2 transcription initiation factor TFIID subunit 12 isoform X1

UniProtKB/TrEMBL

Q3UT56

Conserved Domains (1) summary

cd07981
Location:92 → 160

TAF12; TATA Binding Protein (TBP) Associated Factor 12