Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myh1provided by MGI
Official Full Name: myosin, heavy polypeptide 1, skeletal muscle, adultprovided by MGI
Primary source: MGI:MGI:1339711
See related: Ensembl:ENSMUSG00000056328 AllianceGenome:MGI:1339711
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IId; MdMs; IId/x; Myhs-f; Myhsf2; MHC2X/D; Myhs-f2; MHC-2X/D; MYHC-IIX; MyHC-IId/x; MyHC-IIx/d; A530084A17Rik
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in muscle contraction. Located in A band and intercalated disc. Is expressed in several structures, including gonad; gut; hemolymphoid system gland; integumental system; and skeletal musculature. Orthologous to human MYH1 (myosin heavy chain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in mammary gland adult (RPKM 25.2), lung adult (RPKM 11.6) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 40.59 cM

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (67090922..67115401)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (67200102..67224577)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.
Title: Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.
Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1.
Title: Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1.
Oleic acid up-regulates myosin heavy chain (MyHC) 1 expression and increases mitochondrial mass and maximum respiration in C2C12 myoblasts.
Title: Oleic acid up-regulates myosin heavy chain (MyHC) 1 expression and increases mitochondrial mass and maximum respiration in C2C12 myoblasts.
Data suggest that single muscle immobilization induces a shift of myosin heavy chain (MHC) isoforms composition toward a faster contractile phenotype and decreases the polymorphic profile of single fibres, and that activation of p38 and JNK could be a potential mechanism involved in these contractile phenotype modifications during muscle immobilization.
Title: Single Muscle Immobilization Decreases Single-Fibre Myosin Heavy Chain Polymorphism: Possible Involvement of p38 and JNK MAP Kinases.
The maintenance of the relative expression of slow MHC-1 protein is independent of neuromuscular activity in mice.
Title: Slow myosin heavy chain expression in the absence of muscle activity.
p38alpha/beta MAPKs-mediated coactivator recruitment at a proximal MEF-2 site is important for MyHCIId/x gene regulation in skeletal muscle.
Title: The p38alpha/beta mitogen-activated protein kinases mediate recruitment of CREB-binding protein to preserve fast myosin heavy chain IId/x gene activity in myotubes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Myh1 (e-PCR), detects polymorphism
- UniSTS:143949

Myh1 (e-PCR), detects polymorphism
- UniSTS:143950

Myh1 (e-PCR), detects polymorphism
- UniSTS:143951

Myh1 (e-PCR), detects polymorphism
- UniSTS:265577

380N16T7 (e-PCR), detects polymorphism
- UniSTS:140940

RH65760 (e-PCR)
- UniSTS:19394

Myh1 (e-PCR), detects polymorphism
- UniSTS:257230

Myh1 (e-PCR), detects polymorphism
- UniSTS:515318

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle contraction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in A band	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
part_of muscle myosin complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myosin-1

Names: myHC-2x; myosin heavy chain 1; myosin heavy chain 2X; myosin heavy chain, skeletal muscle, adult 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030679.2 → NP_109604.1 myosin-1

See identical proteins and their annotated locations for NP_109604.1

Status: VALIDATED

Source sequence(s)

AK041122, BC108329

Consensus CDS

CCDS24855.1

UniProtKB/Swiss-Prot

Q32P18, Q5SX40

UniProtKB/TrEMBL

B2RWX0

Related

ENSMUSP00000117569.2, ENSMUST00000124516.8

Conserved Domains (3) summary

cd14910
Location:100 → 773

MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain

pfam01576
Location:853 → 1930

Myosin_tail_1; Myosin tail

pfam02736
Location:35 → 73

Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

67090922..67115401

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314318.3 → XP_017169807.1 myosin-1 isoform X1

UniProtKB/Swiss-Prot

Q32P18, Q5SX40

UniProtKB/TrEMBL

B2RWX0

Related

ENSMUSP00000018637.9, ENSMUST00000018637.15

Conserved Domains (3) summary

cd14910
Location:100 → 773

MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain

pfam01576
Location:853 → 1930

Myosin_tail_1; Myosin tail

pfam02736
Location:35 → 73

Myosin_N; Myosin N-terminal SH3-like domain