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    Uvssa UV stimulated scaffold protein A [ Mus musculus (house mouse) ]

    Gene ID: 71101, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Uvssaprovided by MGI
    Official Full Name
    UV stimulated scaffold protein Aprovided by MGI
    Primary source
    MGI:MGI:1918351
    See related
    Ensembl:ENSMUSG00000037355 AllianceGenome:MGI:1918351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa1530; mKIAA1530; 4933407H18Rik; D330017J19Rik
    Summary
    Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in protein ubiquitination; response to UV; and transcription-coupled nucleotide-excision repair. Predicted to be located in nucleoplasm. Predicted to be active in chromosome. Human ortholog(s) of this gene implicated in UV-sensitive syndrome. Orthologous to human UVSSA (UV stimulated scaffold protein A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.8), limb E14.5 (RPKM 3.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Uvssa in Genome Data Viewer
    Location:
    5 B1; 5 17.6 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (33535868..33578243)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33378523..33420899)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20465 Neighboring gene STARR-seq mESC enhancer starr_12818 Neighboring gene STARR-seq mESC enhancer starr_12819 Neighboring gene macrophage erythroblast attacher Neighboring gene STARR-positive B cell enhancer ABC_E4752 Neighboring gene STARR-positive B cell enhancer ABC_E11724 Neighboring gene NK1 homeobox 1 Neighboring gene STARR-positive B cell enhancer ABC_E10313 Neighboring gene STARR-seq mESC enhancer starr_12825 Neighboring gene STARR-seq mESC enhancer starr_12826 Neighboring gene STARR-positive B cell enhancer ABC_E6317 Neighboring gene family with sequence similarity 53, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to UV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription-coupled nucleotide-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UV-stimulated scaffold protein A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081101.2 → NP_001074570.1  UV-stimulated scaffold protein A

      See identical proteins and their annotated locations for NP_001074570.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC145072, AK016722, AK040506, BB590196, BM941364
      Consensus CDS
      CCDS39064.1
      UniProtKB/Swiss-Prot
      B2RQ84, B7ZN03, Q3U1A8, Q6P7V8, Q6ZPN7, Q9D479
      Related
      ENSMUSP00000085170.6, ENSMUST00000087864.12
      Conserved Domains (1) summary
      pfam09740
      Location:505 → 608
      DUF2043; Uncharacterized conserved protein (DUF2043)

    2. NM_027674.1 → NP_081950.1  UV-stimulated scaffold protein A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC145072
      Consensus CDS
      CCDS39064.1
      UniProtKB/Swiss-Prot
      B2RQ84, B7ZN03, Q3U1A8, Q6P7V8, Q6ZPN7, Q9D479
      Related
      ENSMUSP00000144400.2, ENSMUST00000202816.2
      Conserved Domains (1) summary
      pfam09740
      Location:505 → 608
      DUF2043; Uncharacterized conserved protein (DUF2043)

    RNA

    1. NR_153107.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC145072, AK040506
      Related
      ENSMUST00000202046.4

    2. NR_153108.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC145072

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      33535868..33578243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504109.3 → XP_006504172.1  UV-stimulated scaffold protein A isoform X2

      Conserved Domains (1) summary
      pfam09740
      Location:291 → 394
      DUF2043; Uncharacterized conserved protein (DUF2043)

    2. XM_006504108.5 → XP_006504171.1  UV-stimulated scaffold protein A isoform X1

      See identical proteins and their annotated locations for XP_006504171.1

      UniProtKB/Swiss-Prot
      B2RQ84, B7ZN03, Q3U1A8, Q6P7V8, Q6ZPN7, Q9D479
      Conserved Domains (1) summary
      pfam09740
      Location:505 → 608
      DUF2043; Uncharacterized conserved protein (DUF2043)

    RNA

    1. XR_004942561.1 RNA Sequence

    2. XR_004942560.1 RNA Sequence

    3. XR_003955710.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D479.2 GenPept UniProtKB/Swiss-Prot:Q9D479

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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