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    Stk11ip serine/threonine kinase 11 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 71728, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Stk11ipprovided by MGI
    Official Full Name
    serine/threonine kinase 11 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1918978
    See related
    Ensembl:ENSMUSG00000026213 AllianceGenome:MGI:1918978
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LIP1; LKB1IP; 1200014D22Rik
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in protein localization. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytoplasm. Orthologous to human STK11IP (serine/threonine kinase 11 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 15.1), spleen adult (RPKM 15.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stk11ip in Genome Data Viewer
    Location:
    1 C4; 1 39.16 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75498173..75513979)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75521529..75537335)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene obscurin-like 1 Neighboring gene STARR-seq mESC enhancer starr_01360 Neighboring gene inhibin alpha Neighboring gene STARR-positive B cell enhancer ABC_E5772 Neighboring gene STARR-positive B cell enhancer ABC_E5773 Neighboring gene STARR-positive B cell enhancer ABC_E4325 Neighboring gene predicted gene 15183 Neighboring gene solute carrier family 4 (anion exchanger), member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification. Zi Z, et al. Nat Commun, 2022 Apr 1. PMID 35365663, Free PMC Article
    2. LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway. Tian M, et al. J Cell Mol Med, 2021 Mar. PMID 33486894, Free PMC Article
    3. Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1. Morén A, et al. J Biol Chem, 2011 Jan 7. PMID 20974850, Free PMC Article
    4. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. Smith DP, et al. Hum Mol Genet, 2001 Dec 1. PMID 11741830
    5. Proteomic and yeast 2-hybrid screens to identify PTEN binding partners. Tibarewal P, et al. Adv Biol Regul, 2024 Jan. PMID 37839992

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification.
      Title: Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification.
    2. LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway.
      Title: LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway.
    3. LKB1 and LIP1 provide negative control of TGFbeta signaling.
      Title: Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 11-interacting protein
    Names
    LKB1-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432914.1 → NP_001419843.1  serine/threonine-protein kinase 11-interacting protein

      Status: VALIDATED

      Source sequence(s)
      AC115011
      UniProtKB/Swiss-Prot
      Q3TAA7, Q6P7J8, Q9DBT7

    2. NM_027886.4 → NP_082162.3  serine/threonine-protein kinase 11-interacting protein

      See identical proteins and their annotated locations for NP_082162.3

      Status: VALIDATED

      Source sequence(s)
      AC115011
      Consensus CDS
      CCDS15079.1
      UniProtKB/Swiss-Prot
      Q3TAA7, Q6P7J8, Q9DBT7
      Related
      ENSMUSP00000027414.10, ENSMUST00000027414.16
      Conserved Domains (4) summary
      sd00031
      Location:211 → 233
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:234 → 274
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:236 → 291
      LRR_8; Leucine rich repeat
      pfam15904
      Location:4 → 94
      LIP1; LKB1 serine/threonine kinase interacting protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75498173..75513979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243043.1 → XP_030098903.1  serine/threonine-protein kinase 11-interacting protein isoform X2

    2. XM_036153689.1 → XP_036009582.1  serine/threonine-protein kinase 11-interacting protein isoform X1

      Related
      ENSMUST00000140963.8
      Conserved Domains (3) summary
      COG4886
      Location:14 → 318
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:124 → 146
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:104 → 234
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TAA7.1 GenPept UniProtKB/Swiss-Prot:Q3TAA7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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