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    Brox BRO1 domain and CAAX motif containing [ Mus musculus (house mouse) ]

    Gene ID: 71678, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Broxprovided by MGI
    Official Full Name
    BRO1 domain and CAAX motif containingprovided by MGI
    Primary source
    MGI:MGI:1918928
    See related
    Ensembl:ENSMUSG00000046836 AllianceGenome:MGI:1918928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610010K06Rik
    Summary
    Predicted to be involved in mitotic nuclear membrane reassembly. Predicted to be located in nuclear envelope. Orthologous to human BROX (BRO1 domain and CAAX motif containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 25.6), whole brain E14.5 (RPKM 20.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Brox in Genome Data Viewer
    Location:
    1; 1 H5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (183057916..183078839, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (183276352..183297298, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene dispatched RND transporter family member 1 Neighboring gene protein phosphatase 2A inhibitor-2 I-2PP2A-related Neighboring gene family with sequence similarity 177 member B Neighboring gene predicted gene, 34287 Neighboring gene axin interactor, dorsalization associated Neighboring gene MIA SH3 domain ER export factor 3 Neighboring gene predicted gene, 34102 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4). Ichioka F, et al. FEBS J, 2008 Feb. PMID 18190528
    2. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitotic nuclear membrane reassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic nuclear membrane reassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BRO1 domain-containing protein BROX
    Names
    BRO1 domain- and CAAX motif-containing protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357242.2 → NP_001344171.1  BRO1 domain-containing protein BROX

      Status: VALIDATED

      Source sequence(s)
      AEKQ02108040, CAAA01119163
      Consensus CDS
      CCDS56662.1
      UniProtKB/Swiss-Prot
      Q8BWM8, Q8K2Q7, Q9DCT7
      Related
      ENSMUSP00000132333.4, ENSMUST00000163528.8
      Conserved Domains (1) summary
      cd09243
      Location:4 → 356
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins

    2. NM_027861.4 → NP_082137.1  BRO1 domain-containing protein BROX

      See identical proteins and their annotated locations for NP_082137.1

      Status: VALIDATED

      Source sequence(s)
      AEKQ02108040, CAAA01119163
      Consensus CDS
      CCDS56662.1
      UniProtKB/Swiss-Prot
      Q8BWM8, Q8K2Q7, Q9DCT7
      Related
      ENSMUSP00000061345.6, ENSMUST00000057062.12
      Conserved Domains (1) summary
      cd09243
      Location:4 → 356
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins

    RNA

    1. NR_151660.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AEKQ02108040, CAAA01119163

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      183057916..183078839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535600.5 → XP_006535663.1  BRO1 domain-containing protein BROX isoform X3

      Conserved Domains (1) summary
      cl14649
      Location:1 → 243
      BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains

    2. XM_006535599.5 → XP_006535662.1  BRO1 domain-containing protein BROX isoform X2

      Conserved Domains (1) summary
      cd09243
      Location:1 → 300
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins

    3. XM_036153688.1 → XP_036009581.1  BRO1 domain-containing protein BROX isoform X3

      Conserved Domains (1) summary
      cl14649
      Location:1 → 243
      BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains

    4. XM_030243025.1 → XP_030098885.1  BRO1 domain-containing protein BROX isoform X2

      Conserved Domains (1) summary
      cd09243
      Location:1 → 300
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins

    5. XM_006535598.4 → XP_006535661.1  BRO1 domain-containing protein BROX isoform X1

      See identical proteins and their annotated locations for XP_006535661.1

      UniProtKB/Swiss-Prot
      Q8BWM8, Q8K2Q7, Q9DCT7
      Conserved Domains (1) summary
      cd09243
      Location:4 → 356
      BRO1_Brox_like; Protein-interacting Bro1-like domain of human Brox1 and related proteins

    RNA

    1. XR_389720.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2Q7.1 GenPept UniProtKB/Swiss-Prot:Q8K2Q7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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