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    Setd7 SET domain containing (lysine methyltransferase) 7 [ Mus musculus (house mouse) ]

    Gene ID: 73251, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Setd7provided by MGI
    Official Full Name
    SET domain containing (lysine methyltransferase) 7provided by MGI
    Primary source
    MGI:MGI:1920501
    See related
    Ensembl:ENSMUSG00000037111 AllianceGenome:MGI:1920501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KMT7; Set7; H3K4MT; Set7/9; mKIAA1717; 1600028F23Rik
    Summary
    Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Acts upstream of or within heterochromatin organization. Predicted to be located in nucleolus. Predicted to be active in chromosome and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; musculature; and nervous system. Orthologous to human SETD7 (SET domain containing 7, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 24.0), bladder adult (RPKM 20.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Setd7 in Genome Data Viewer
    Location:
    3 C; 3 22.5 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51422740..51468519, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51515318..51560823, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51314972-51315081 Neighboring gene STARR-seq mESC enhancer starr_07615 Neighboring gene RAB33B, member RAS oncogene family Neighboring gene RIKEN cDNA 5031434O11 gene Neighboring gene predicted gene, 36008 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51358072-51358308 Neighboring gene STARR-positive B cell enhancer mm9_chr3:51363442-51363743 Neighboring gene STARR-seq mESC enhancer starr_07617 Neighboring gene STARR-seq mESC enhancer starr_07618 Neighboring gene STARR-seq mESC enhancer starr_07619 Neighboring gene STARR-seq mESC enhancer starr_07620 Neighboring gene STARR-positive B cell enhancer ABC_E11183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51440808-51440917 Neighboring gene STARR-seq mESC enhancer starr_07621 Neighboring gene STARR-seq mESC enhancer starr_07622 Neighboring gene STARR-seq mESC enhancer starr_07623 Neighboring gene STARR-seq mESC enhancer starr_07624 Neighboring gene predicted gene, 38247 Neighboring gene microsomal glutathione S-transferase 2 Neighboring gene mastermind like transcriptional coactivator 3 Neighboring gene predicted gene, 46803

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction. Lunardon G, et al. Clin Sci (Lond), 2022 Nov 30. PMID 36285636
    2. The methyltransferase Set7/9 (Setd7) is dispensable for the p53-mediated DNA damage response in vivo. Campaner S, et al. Mol Cell, 2011 Aug 19. PMID 21855806
    3. Expression and function of Set7/9 in pancreatic islets. Ogihara T, et al. Islets, 2009 Nov-Dec. PMID 21099283, Free PMC Article
    4. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Barsyte-Lovejoy D, et al. Proc Natl Acad Sci U S A, 2014 Sep 2. PMID 25136132, Free PMC Article
    5. Set7 mediated interactions regulate transcriptional networks in embryonic stem cells. Tuano NK, et al. Nucleic Acids Res, 2016 Nov 2. PMID 27439711, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction.
      Title: Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction.
    2. LncRNA SNHG15 regulates hypoxic-ischemic brain injury via miR-153-3p/SETD7 axis.
      Title: LncRNA SNHG15 regulates hypoxic-ischemic brain injury via miR-153-3p/SETD7 axis.
    3. Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development.
      Title: Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development.
    4. SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF1alpha.
      Title: SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF‑1α.
    5. IL-6 regulates the bone metabolism and inflammatory microenvironment in aging mice by inhibiting Setd7.
      Title: IL-6 regulates the bone metabolism and inflammatory microenvironment in aging mice by inhibiting Setd7.
    6. SetD7 (Set7/9) is a novel target of PPARgamma that promotes the adaptive pancreatic beta-cell glycemic response.
      Title: SetD7 (Set7/9) is a novel target of PPARγ that promotes the adaptive pancreatic β-cell glycemic response.
    7. SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis.
      Title: SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis.
    8. Murine peritoneal fibrosis was induced by intraperitoneal injection of methylglyoxal (MGO). SET7/9 expression was elevated in MGO-injected mice.
      Title: Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis.
    9. spinal SET7/9 may contribute to the maintenance of CIBP
      Title: Spinal SET7/9 may contribute to the maintenance of cancer-induced bone pain in mice.
    10. the methyltransferase Set9 potentiates TGF-beta signaling by targeting Smad7, an inhibitory downstream effector.
      Title: SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K4 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables p53 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-lysine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heterochromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heterochromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heterochromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-lysine dimethylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-lysine dimethylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within peptidyl-lysine methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-lysine methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-lysine monomethylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-lysine monomethylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase SETD7
    Names
    H3-K4 methyltransferase
    H3-K4-HMTase SETD7
    SET domain-containing protein 7
    histone H3-K4 methyltransferase SETD7
    NP_542983.3
    XP_036019246.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080793.6 → NP_542983.3  histone-lysine N-methyltransferase SETD7

      See identical proteins and their annotated locations for NP_542983.3

      Status: VALIDATED

      Source sequence(s)
      AC102860
      Consensus CDS
      CCDS17341.1
      UniProtKB/Swiss-Prot
      Q6ZPJ6, Q80UU3, Q8C7Y6, Q8VHL1
      Related
      ENSMUSP00000043492.8, ENSMUST00000037141.9
      Conserved Domains (1) summary
      smart00317
      Location:226 → 342
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      51422740..51468519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163353.1 → XP_036019246.1  histone-lysine N-methyltransferase SETD7 isoform X1

      Conserved Domains (1) summary
      cd10530
      Location:70 → 199
      SET_SETD7; SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins

    RNA

    1. XR_004941406.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHL1.2 GenPept UniProtKB/Swiss-Prot:Q8VHL1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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