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    Zfp287 zinc finger protein 287 [ Mus musculus (house mouse) ]

    Gene ID: 170740, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp287provided by MGI
    Official Full Name
    zinc finger protein 287provided by MGI
    Primary source
    MGI:MGI:2176561
    See related
    Ensembl:ENSMUSG00000005267 AllianceGenome:MGI:2176561
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Skat2; SKAT-2; Znf287; mszf16; mszf74; zfp-287; B230333C16Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within positive regulation of DNA-templated transcription and regulation of cytokine production. Predicted to be active in nucleus. Is expressed in bladder; central nervous system; head; and ureter. Orthologous to human ZNF287 (zinc finger protein 287). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 1.9), CNS E14 (RPKM 1.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp287 in Genome Data Viewer
    Location:
    11 B2; 11 38.62 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62583270..62622749, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62692444..62731912, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 75A Neighboring gene leucine rich repeat containing 75A, opposite strand 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:62462281-62462390 Neighboring gene membrane magnesium transporter 2 Neighboring gene nuclear encoded tRNA trytophan 8 (anticodon CCA) Neighboring gene WD repeat and SOCS box-containing 2, pseudogene Neighboring gene zinc finger protein 286

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of SKAT-2, a novel Th2-specific zinc finger gene. Blanchard AD, et al. Eur J Immunol, 2000 Nov. PMID 11093124
    2. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 287
    Names
    zinc finger protein SKAT-2
    zinc finger protein SKAT2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382823.1 → NP_001369752.1  zinc finger protein 287 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627097
      UniProtKB/TrEMBL
      Q3UZW0
      Related
      ENSMUSP00000121717.2, ENSMUST00000150336.8
      Conserved Domains (2) summary
      smart00349
      Location:166 → 223
      KRAB; krueppel associated box
      pfam02023
      Location:39 → 122
      SCAN; SCAN domain

    2. NM_001382824.1 → NP_001369753.1  zinc finger protein 287 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL627097
      UniProtKB/TrEMBL
      Q3UY44
      Related
      ENSMUSP00000117179.2, ENSMUST00000128370.2
      Conserved Domains (2) summary
      smart00349
      Location:166 → 223
      KRAB; krueppel associated box
      pfam02023
      Location:39 → 122
      SCAN; SCAN domain

    3. NM_133208.3 → NP_573471.2  zinc finger protein 287 isoform 1

      See identical proteins and their annotated locations for NP_573471.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL627097
      Consensus CDS
      CCDS24830.1
      UniProtKB/Swiss-Prot
      Q8CDU3, Q9EQB9
      Related
      ENSMUSP00000005399.4, ENSMUST00000005399.10
      Conserved Domains (5) summary
      smart00349
      Location:166 → 223
      KRAB; krueppel associated box
      COG5048
      Location:420 → 753
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:424 → 444
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:394 → 416
      zf-C2H2; Zinc finger, C2H2 type
      cl02605
      Location:39 → 138
      SCAN; SCAN oligomerization domain

    RNA

    1. NR_168576.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL627097

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      62583270..62622749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156368.1 → XP_036012261.1  zinc finger protein 287 isoform X2

      UniProtKB/TrEMBL
      Q3UZW0
      Conserved Domains (2) summary
      smart00349
      Location:166 → 223
      KRAB; krueppel associated box
      pfam02023
      Location:39 → 122
      SCAN; SCAN domain

    2. XM_036156369.1 → XP_036012262.1  zinc finger protein 287 isoform X2

      UniProtKB/TrEMBL
      Q3UZW0
      Conserved Domains (2) summary
      smart00349
      Location:166 → 223
      KRAB; krueppel associated box
      pfam02023
      Location:39 → 122
      SCAN; SCAN domain

    3. XM_036156367.1 → XP_036012260.1  zinc finger protein 287 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:238 → 571
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:242 → 262
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:212 → 234
      zf-C2H2; Zinc finger, C2H2 type
      cl02581
      Location:3 → 41
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    RNA

    1. XR_004936821.1 RNA Sequence

    2. XR_004936817.1 RNA Sequence

    3. XR_004936820.1 RNA Sequence

    4. XR_879531.4 RNA Sequence

    5. XR_004936819.1 RNA Sequence

    6. XR_004936818.1 RNA Sequence

    7. XR_879525.4 RNA Sequence

    8. XR_879527.4 RNA Sequence

    9. XR_004936811.1 RNA Sequence

    10. XR_004936810.1 RNA Sequence

    11. XR_004936812.1 RNA Sequence

    12. XR_001779891.3 RNA Sequence

    13. XR_001779892.3 RNA Sequence

    14. XR_004936809.1 RNA Sequence

    15. XR_004936807.1 RNA Sequence

    16. XR_004936808.1 RNA Sequence

    17. XR_004936816.1 RNA Sequence

    18. XR_004936814.1 RNA Sequence

    19. XR_004936815.1 RNA Sequence

    20. XR_004936813.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQB9.2 GenPept UniProtKB/Swiss-Prot:Q9EQB9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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