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    Lrcol1 leucine rich colipase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 381667, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrcol1provided by MGI
    Official Full Name
    leucine rich colipase-like 1provided by MGI
    Primary source
    MGI:MGI:2686525
    See related
    Ensembl:ENSMUSG00000072754 AllianceGenome:MGI:2686525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clpsl3; Gm1679
    Summary
    Predicted to enable enzyme activator activity. Predicted to be involved in digestion and lipid catabolic process. Predicted to be located in extracellular region. Orthologous to human LRCOL1 (leucine rich colipase like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 69.1) See more
    Orthologs
    human all
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    Genomic context

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    See Lrcol1 in Genome Data Viewer
    Location:
    5 F; 5 53.5 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110492373..110503960)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110344507..110356094)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene polymerase (DNA directed), epsilon Neighboring gene predicted gene, 26277 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 2 Neighboring gene fibrosin-like 1 Neighboring gene STARR-seq mESC enhancer starr_13955 Neighboring gene STARR-positive B cell enhancer ABC_E3598 Neighboring gene STARR-seq mESC enhancer starr_13957 Neighboring gene predicted gene, 32996

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction†. Sun J, et al. Biol Reprod, 2020 Aug 4. PMID 32588039, Free PMC Article
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich colipase-like protein 1
    Names
    colipase-like protein 3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310709.1 → NP_001297638.1  leucine-rich colipase-like protein 1 precursor

      See identical proteins and their annotated locations for NP_001297638.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the protein.
      Source sequence(s)
      BX630968, JQ258939
      Consensus CDS
      CCDS80364.1
      UniProtKB/Swiss-Prot
      B9EJP8, H9C9P1, Q3URS3
      Related
      ENSMUSP00000139397.2, ENSMUST00000185691.7
      Conserved Domains (1) summary
      pfam15083
      Location:66 → 155
      Colipase-like

    RNA

    1. NR_132326.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate internal exon and uses an alternate internal splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BX630968, JQ258940
      Related
      ENSMUST00000186408.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      110492373..110503960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535032.2 → XP_006535095.1  leucine-rich colipase-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006535095.1

      UniProtKB/Swiss-Prot
      B9EJP8, H9C9P1, Q3URS3
      Conserved Domains (1) summary
      pfam15083
      Location:66 → 155
      Colipase-like

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033459.3: Suppressed sequence

      Description
      NM_001033459.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3URS3.2 GenPept UniProtKB/Swiss-Prot:Q3URS3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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