Pirt phosphoinositide-interacting regulator of transient receptor potential channels [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pirtprovided by MGI
Official Full Name: phosphoinositide-interacting regulator of transient receptor potential channelsprovided by MGI
Primary source: MGI:MGI:2443635
See related: Ensembl:ENSMUSG00000048070 AllianceGenome:MGI:2443635
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A530088H08Rik
Summary: Enables phosphatidylinositol bisphosphate binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and transmembrane transporter binding activity. Acts upstream of or within behavioral response to pain; positive regulation of cation channel activity; and response to heat. Located in plasma membrane. Is expressed in gut; nervous system; and olfactory epithelium. Orthologous to human PIRT (phosphoinositide interacting regulator of transient receptor potential channels). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 3.2), stomach adult (RPKM 1.7) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 40.59 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (66802731..66820703)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (66911905..66929877)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pirt deficient female mice have an increased body weight and impaired glucose tolerance relative to wild-type (WT) mice. Pirt is dispensable for TRPM8-induced brown adipose tissue thermogenesis in vivo.
Title: Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice.
Using comparative electrophysiology experiments, the study identified species-dependent differences between the human and mouse TRPM8-PIRT complexes. It found that human PIRT attenuated human TPRM8 conductance, unlike mouse PIRT, which enhanced mouse TRPM8 conductance.
Title: Phosphoinositide-interacting regulator of TRP (PIRT) has opposing effects on human and mouse TRPM8 ion channels.
Results show that mechanical allodynia and thermal hyperalgesia were alleviated in Pirt-/- mice in chronic constriction injury (CCI) model. Taken together, Pirt together with transient receptor potential vanilloid channel 1 is involved in CCI-induced neuropathic pain.
Title: Pirt Together with TRPV1 Is Involved in the Regulation of Neuropathic Pain.
Pirt regulates TRPM8 channel activity by increasing the single channel conductance.
Title: Phosphoinositide interacting regulator of TRP (Pirt) enhances TRPM8 channel activity in vitro via increasing channel conductance.
These results demonstrate that Pirt is an endogenous regulator of P2X3 in bladder function.
Title: Pirt reduces bladder overactivity by inhibiting purinergic receptor P2X3.
Pirt plays an important role in mice uterine contraction-induced pain.
Title: Pirt contributes to uterine contraction-induced pain in mice.
Pirt regulates the function of TRPM8 and its role in detecting cold.
Title: Pirt functions as an endogenous regulator of TRPM8.
Pirt contributes to both histaminergic and nonhistaminergic itch and, crucially, is involved in forms of itch that are both TRPV1-dependent and -independent.
Title: Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch.
Pirt is a key component of the TRPV1 complex and positively regulates TRPV1 activity.
Title: Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphoinositide-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.