Prss53 serine protease 53 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss53provided by MGI
Official Full Name: serine protease 53provided by MGI
Primary source: MGI:MGI:2652890
See related: Ensembl:ENSMUSG00000044139 AllianceGenome:MGI:2652890
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pol3s; mFLJ00289
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Orthologous to human PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 2.8), liver adult (RPKM 2.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.81 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (127484616..127490594, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127885444..127892965, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene.
Title: Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene.
Identification of protease serine S1 family member 53 as a mitochondrial protein in murine islet beta cells.
Title: Identification of protease serine S1 family member 53 as a mitochondrial protein in murine islet beta cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine protease 53

Names: Bc039632-like protein; polyserase-3; polyserine protease 3; protease, serine 53

NP_001074737.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081268.1 → NP_001074737.1 serine protease 53 precursor

See identical proteins and their annotated locations for NP_001074737.1

Status: PROVISIONAL

Source sequence(s)

AC149222

Consensus CDS

CCDS52409.1

UniProtKB/Swiss-Prot

Q571E5, Q8CFX9

UniProtKB/TrEMBL

B2RX64, B7ZWH8

Related

ENSMUSP00000112972.2, ENSMUST00000121394.3

Conserved Domains (1) summary

cd00190
Location:45 → 271

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...