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    Klhl13 kelch-like 13 [ Mus musculus (house mouse) ]

    Gene ID: 67455, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klhl13provided by MGI
    Official Full Name
    kelch-like 13provided by MGI
    Primary source
    MGI:MGI:1914705
    See related
    Ensembl:ENSMUSG00000036782 AllianceGenome:MGI:1914705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bklhd2; 1200009K10Rik; D130072F20Rik
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination and regulation of cytokinesis. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, including brain; diaphragm; limb segment; skeletal musculature; and spinal cord mantle layer. Orthologous to human KLHL13 (kelch like family member 13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 72.4), CNS E18 (RPKM 17.0) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhl13 in Genome Data Viewer
    Location:
    X A2; X 17.22 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (23085510..23231340, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (23219271..23365161, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46917 Neighboring gene VISTA enhancer mm1395 Neighboring gene predicted gene, 54074 Neighboring gene predicted gene, 26131 Neighboring gene STARR-seq mESC enhancer starr_46918 Neighboring gene STARR-seq mESC enhancer starr_46919 Neighboring gene STARR-seq mESC enhancer starr_46920 Neighboring gene STARR-seq mESC enhancer starr_46924 Neighboring gene STARR-seq mESC enhancer starr_46925 Neighboring gene STARR-seq mESC enhancer starr_46926 Neighboring gene cyclin-dependent kinase 2 interacting protein pseudogene Neighboring gene WD repeat domain 44 Neighboring gene STARR-seq mESC enhancer starr_46927 Neighboring gene STARR-seq mESC enhancer starr_46928 Neighboring gene testis derived transcript pseudogene Neighboring gene testin LIM domain protein like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network. Pulcrano S, et al. J Neurosci, 2023 Nov 29. PMID 37816598, Free PMC Article
    2. Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue. Duteil D, et al. Cell Rep, 2016 Oct 18. PMID 27760309, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 13
    Names
    BTB and kelch domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290476.2 → NP_001277405.1  kelch-like protein 13 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start site, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AI451128, AK004677, AL773552
      Consensus CDS
      CCDS72348.1
      UniProtKB/TrEMBL
      Q497T4
      Related
      ENSMUSP00000110974.3, ENSMUST00000115319.9
      Conserved Domains (2) summary
      PHA03098
      Location:85 → 628
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:372 → 420
      Kelch; KELCH repeat [structural motif]

    2. NM_001310466.1 → NP_001297395.1  kelch-like protein 13 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start site, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AI451128, AK004677, AL773552
      Consensus CDS
      CCDS81105.1
      UniProtKB/TrEMBL
      Q497T4
      Related
      ENSMUSP00000110971.3, ENSMUST00000115316.9
      Conserved Domains (2) summary
      PHA03098
      Location:77 → 620
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:364 → 412
      Kelch; KELCH repeat [structural motif]

    3. NM_001381891.1 → NP_001368820.1  kelch-like protein 13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL773552, AL808116
      UniProtKB/TrEMBL
      Q497T4
      Conserved Domains (3) summary
      PHA03098
      Location:97 → 640
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:384 → 432
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:74 → 201
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    4. NM_001381892.1 → NP_001368821.1  kelch-like protein 13 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL773552, AL808116
      UniProtKB/TrEMBL
      Q497T4
      Conserved Domains (3) summary
      PHA03098
      Location:97 → 640
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:384 → 432
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:74 → 201
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    5. NM_001381893.1 → NP_001368822.1  kelch-like protein 13 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL773552
      UniProtKB/Swiss-Prot
      A2AL86, A2AL87, A2AL88, A2AL89, Q80TF4, Q9DBY7
      UniProtKB/TrEMBL
      Q497T4
      Conserved Domains (3) summary
      PHA03098
      Location:91 → 634
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:378 → 426
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:68 → 195
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    6. NM_001381894.1 → NP_001368823.1  kelch-like protein 13 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL773552
      UniProtKB/Swiss-Prot
      A2AL86, A2AL87, A2AL88, A2AL89, Q80TF4, Q9DBY7
      UniProtKB/TrEMBL
      Q497T4
      Related
      ENSMUSP00000110972.3, ENSMUST00000115317.9
      Conserved Domains (3) summary
      PHA03098
      Location:91 → 634
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:378 → 426
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:68 → 195
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    7. NM_001381895.1 → NP_001368824.1  kelch-like protein 13 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL773552, AL808116
      UniProtKB/TrEMBL
      Q497T4
      Conserved Domains (3) summary
      PHA03098
      Location:75 → 618
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:362 → 410
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:52 → 179
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    8. NM_001381896.1 → NP_001368825.1  kelch-like protein 13 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL773552, AL808116
      UniProtKB/TrEMBL
      Q497T4
      Related
      ENSMUSP00000041190.5, ENSMUST00000035973.5
      Conserved Domains (3) summary
      PHA03098
      Location:75 → 618
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:362 → 410
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:52 → 179
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    9. NM_026167.4 → NP_080443.1  kelch-like protein 13 isoform 1

      See identical proteins and their annotated locations for NP_080443.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shortest isoform (1).
      Source sequence(s)
      AI451128, AK004677, BY136647
      Consensus CDS
      CCDS40891.1
      UniProtKB/TrEMBL
      Q497T4
      Conserved Domains (3) summary
      PHA03098
      Location:75 → 618
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:362 → 410
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:52 → 179
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      23085510..23231340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251489.2 → XP_030107349.1  kelch-like protein 13 isoform X1

      UniProtKB/TrEMBL
      Q497T4
      Conserved Domains (3) summary
      PHA03098
      Location:97 → 640
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:384 → 432
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:74 → 201
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    2. XM_011247487.3 → XP_011245789.1  kelch-like protein 13 isoform X1

      See identical proteins and their annotated locations for XP_011245789.1

      UniProtKB/TrEMBL
      Q497T4
      Conserved Domains (3) summary
      PHA03098
      Location:97 → 640
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:384 → 432
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:74 → 201
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    3. XM_011247492.4 → XP_011245794.1  kelch-like protein 13 isoform X4

      See identical proteins and their annotated locations for XP_011245794.1

      UniProtKB/TrEMBL
      Q497T4
      Conserved Domains (3) summary
      PHA03098
      Location:75 → 618
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:362 → 410
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:52 → 179
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    4. XM_036162081.1 → XP_036017974.1  kelch-like protein 13 isoform X4

      UniProtKB/TrEMBL
      Q497T4
      Conserved Domains (3) summary
      PHA03098
      Location:75 → 618
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:362 → 410
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:52 → 179
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    5. XM_036162080.1 → XP_036017973.1  kelch-like protein 13 isoform X4

      UniProtKB/TrEMBL
      Q497T4
      Conserved Domains (3) summary
      PHA03098
      Location:75 → 618
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:362 → 410
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:52 → 179
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    6. XM_011247488.4 → XP_011245790.1  kelch-like protein 13 isoform X2

      UniProtKB/TrEMBL
      Q497T4
      Conserved Domains (3) summary
      PHA03098
      Location:94 → 637
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:381 → 429
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:71 → 198
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    7. XM_036162082.1 → XP_036017975.1  kelch-like protein 13 isoform X5

      UniProtKB/TrEMBL
      Q497T4
      Related
      ENSMUSP00000110968.2, ENSMUST00000115313.8
      Conserved Domains (3) summary
      PHA03098
      Location:41 → 584
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:328 → 376
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:18 → 145
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    8. XM_030251491.2 → XP_030107351.1  kelch-like protein 13 isoform X3

      UniProtKB/Swiss-Prot
      A2AL86, A2AL87, A2AL88, A2AL89, Q80TF4, Q9DBY7
      UniProtKB/TrEMBL
      Q497T4
      Conserved Domains (3) summary
      PHA03098
      Location:91 → 634
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:378 → 426
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:68 → 195
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TF4.3 GenPept UniProtKB/Swiss-Prot:Q80TF4

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