Catsperz cation channel sperm associated auxiliary subunit zeta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Catsperzprovided by MGI
Official Full Name: cation channel sperm associated auxiliary subunit zetaprovided by MGI
Primary source: MGI:MGI:1914327
See related: Ensembl:ENSMUSG00000050623 AllianceGenome:MGI:1914327
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tex40; MLZ-622; 1700019N12Rik; A430107B04Rik
Summary: Involved in flagellated sperm motility; male meiotic nuclear division; and sperm capacitation. Located in sperm principal piece. Part of CatSper complex. Is expressed in alimentary system; genitourinary system; and skin. Orthologous to human CATSPERZ (catsper channel auxiliary subunit zeta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 463.3) See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.08 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6899794..6902748, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6922426..6925380, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeted disruption of Tex40 (CatSperz) reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male subfertility.
Title: CatSperζ regulates the structural continuity of sperm Ca(2+) signaling domains and is required for normal fertility.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)

General gene information

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Markers

UniSTS:166286 (e-PCR)
- UniSTS:166286

Kcnk4 (e-PCR), detects polymorphism
- UniSTS:166286

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiotic nuclear division	IEP Inferred from Expression Pattern more info	PubMed
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm capacitation	IDA Inferred from Direct Assay more info	PubMed
involved_in sperm capacitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CatSper complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CatSper complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in sperm principal piece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm principal piece	IDA Inferred from Direct Assay more info	PubMed
located_in sperm principal piece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cation channel sperm-associated auxiliary subunit zeta

Names: catSper-zeta; catSperzeta; cation channel sperm-associated protein subunit zeta; protein expressed in male leptotene and zygotene spermatocytes 622; testis expressed 40; testis-expressed protein 40; testis-expressed sequence 40 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.