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    Zkscan8 zinc finger with KRAB and SCAN domains 8 [ Mus musculus (house mouse) ]

    Gene ID: 93681, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zkscan8provided by MGI
    Official Full Name
    zinc finger with KRAB and SCAN domains 8provided by MGI
    Primary source
    MGI:MGI:1913815
    See related
    Ensembl:ENSMUSG00000063894 AllianceGenome:MGI:1913815
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LD5-1; Zfp192; 2510038J07Rik; D430019P06Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including central nervous system; early conceptus; eye; and genitourinary system. Orthologous to human ZKSCAN8 (zinc finger with KRAB and SCAN domains 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.0), whole brain E14.5 (RPKM 3.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zkscan8 in Genome Data Viewer
    Location:
    13 A3.1; 13 7.84 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21697391..21715284, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21513221..21531114, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 5B, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5373 Neighboring gene zinc finger protein 389 Neighboring gene predicted gene, 32724 Neighboring gene olfactory receptor family 1 subfamily F member 12 Neighboring gene olfactory receptor family 2 subfamily B member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of SCAN dimerization domains in four gene families. Honer C, et al. Biochim Biophys Acta, 2001 Feb 16. PMID 11342224
    2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein with KRAB and SCAN domains 8
    Names
    zinc finger protein 192

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001251833.1 → NP_001238762.1  zinc finger protein with KRAB and SCAN domains 8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive exons in the CDS, compared to variant 1. The reading frame is not affected and the resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AL589742, BC150775, BY333359
      Consensus CDS
      CCDS88420.1
      UniProtKB/TrEMBL
      A0A286YCX3
      Conserved Domains (3) summary
      smart00431
      Location:48 → 158
      SCAN; leucine rich region
      COG5048
      Location:250 → 502
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:374 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001251834.1 → NP_001238763.1  zinc finger protein with KRAB and SCAN domains 8 isoform 3

      See identical proteins and their annotated locations for NP_001238763.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a different 3' coding region and 3' UTR compared to variant 1. The resulting isoform (3) is much shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BY333359, CX566615
      Consensus CDS
      CCDS56871.1
      UniProtKB/TrEMBL
      Q78WV9
      Related
      ENSMUSP00000106107.3, ENSMUST00000110481.3
      Conserved Domains (1) summary
      pfam02023
      Location:48 → 133
      SCAN; SCAN domain

    3. NM_139141.4 → NP_631880.2  zinc finger protein with KRAB and SCAN domains 8 isoform 1

      See identical proteins and their annotated locations for NP_631880.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK032718, AL589742, BY333359
      Consensus CDS
      CCDS26278.1
      UniProtKB/TrEMBL
      Q8BSL0
      Related
      ENSMUSP00000040248.6, ENSMUST00000045228.12
      Conserved Domains (4) summary
      smart00431
      Location:48 → 158
      SCAN; leucine rich region
      cd07765
      Location:233 → 268
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:322 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:446 → 466
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      21697391..21715284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247476.2 → XP_030103336.1  zinc finger protein with KRAB and SCAN domains 8 isoform X2

      UniProtKB/TrEMBL
      A0A286YCX3
      Related
      ENSMUSP00000153171.2, ENSMUST00000224362.2
      Conserved Domains (3) summary
      smart00431
      Location:48 → 158
      SCAN; leucine rich region
      COG5048
      Location:250 → 502
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:374 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_030247475.1 → XP_030103335.1  zinc finger protein with KRAB and SCAN domains 8 isoform X1

      UniProtKB/TrEMBL
      Q8BSL0
      Conserved Domains (4) summary
      smart00431
      Location:48 → 158
      SCAN; leucine rich region
      cd07765
      Location:233 → 268
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:322 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:446 → 466
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_030247477.1 → XP_030103337.1  zinc finger protein with KRAB and SCAN domains 8 isoform X3

      Conserved Domains (3) summary
      cd07765
      Location:57 → 92
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:146 → 398
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:270 → 290
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_030247474.2 → XP_030103334.1  zinc finger protein with KRAB and SCAN domains 8 isoform X1

      UniProtKB/TrEMBL
      Q8BSL0
      Conserved Domains (4) summary
      smart00431
      Location:48 → 158
      SCAN; leucine rich region
      cd07765
      Location:233 → 268
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:322 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:446 → 466
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_036158230.1 → XP_036014123.1  zinc finger protein with KRAB and SCAN domains 8 isoform X3

      Conserved Domains (3) summary
      cd07765
      Location:57 → 92
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:146 → 398
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:270 → 290
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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