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    HTR1E 5-hydroxytryptamine receptor 1E [ Homo sapiens (human) ]

    Gene ID: 3354, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HTR1Eprovided by HGNC
    Official Full Name
    5-hydroxytryptamine receptor 1Eprovided by HGNC
    Primary source
    HGNC:HGNC:5291
    See related
    Ensembl:ENSG00000168830 MIM:182132; AllianceGenome:HGNC:5291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    5-HT1E
    Summary
    Enables Gi/o-coupled serotonin receptor activity; serotonin binding activity; and serotonin receptor activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary (RPKM 1.3), endometrium (RPKM 0.7) and 4 other tissues See more
    Orthologs
    all
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    Genomic context

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    See HTR1E in Genome Data Viewer
    Location:
    6q14.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (86937528..87016679)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (88146245..88225391)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (87647246..87726397)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene SUZ RNA binding domain containing 1 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 643, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:87291002-87292201 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:87307995-87308547 Neighboring gene MPRA-validated peak5941 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:87380117-87380640 Neighboring gene Sharpr-MPRA regulatory region 4618 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:87433363-87434562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:87440887-87441388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:87441389-87441888 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:87497596-87498795 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:87607342-87607842 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:87607843-87608343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:87647030-87647585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:87647586-87648140 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:87679014-87680213 Neighboring gene ribosomal protein L7 pseudogene 29 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:87748156-87748680 Neighboring gene small integral membrane protein 30-like Neighboring gene RN7SK pseudogene 209

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor. Zgombick JM, et al. Mol Pharmacol, 1992 Aug. PMID 1513320
    2. Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer. Qin X, et al. Theranostics, 2021. PMID 34093864, Free PMC Article
    3. Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. Levy FO, et al. FEBS Lett, 1992 Jan 20. PMID 1733778
    4. Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15. Levy FO, et al. Genomics, 1994 Aug. PMID 8001977
    5. 5-Hydroxytryptamine receptor subtype messenger RNAs in human dorsal root ganglia: a polymerase chain reaction study. Pierce PA, et al. Neuroscience, 1997 Dec. PMID 9316030

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel interaction between neurotrophic factor-alpha1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via beta-arrestin/ERK signaling.
      Title: Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling.
    2. Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer.
      Title: Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer.
    3. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
    4. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association study of the serotoninergic system in migraine in the Spanish population.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled serotonin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables Gi/o-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serotonin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    5-hydroxytryptamine receptor 1E
    Names
    5-HT-1E
    5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
    S31
    serotonin receptor 1E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000865.3 → NP_000856.1  5-hydroxytryptamine receptor 1E

      See identical proteins and their annotated locations for NP_000856.1

      Status: VALIDATED

      Source sequence(s)
      AL157777, AL521170, BC069751, M91467
      Consensus CDS
      CCDS5006.1
      UniProtKB/Swiss-Prot
      E1P503, P28566, Q9P1Y1
      Related
      ENSP00000307766.4, ENST00000305344.7
      Conserved Domains (1) summary
      cd15335
      Location:23 → 355
      7tmA_5-HT1E; serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      86937528..87016679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535789.3 → XP_011534091.1  5-hydroxytryptamine receptor 1E isoform X1

      See identical proteins and their annotated locations for XP_011534091.1

      UniProtKB/Swiss-Prot
      E1P503, P28566, Q9P1Y1
      Conserved Domains (1) summary
      cd15335
      Location:23 → 355
      7tmA_5-HT1E; serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      88146245..88225391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355315.1 → XP_054211290.1  5-hydroxytryptamine receptor 1E isoform X1

      UniProtKB/Swiss-Prot
      E1P503, P28566, Q9P1Y1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28566.1 GenPept UniProtKB/Swiss-Prot:P28566

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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