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    NXT2 nuclear transport factor 2 like export factor 2 [ Homo sapiens (human) ]

    Gene ID: 55916, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NXT2provided by HGNC
    Official Full Name
    nuclear transport factor 2 like export factor 2provided by HGNC
    Primary source
    HGNC:HGNC:18151
    See related
    Ensembl:ENSG00000101888 MIM:300320; AllianceGenome:HGNC:18151
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P15-2
    Summary
    The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]
    Expression
    Broad expression in testis (RPKM 16.8), bone marrow (RPKM 5.3) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NXT2 in Genome Data Viewer
    Location:
    Xq23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (109535824..109544698)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (107983286..107992160)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (108779053..108787927)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:108590655-108591265 Neighboring gene GAPDH pseudogene 77 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:108617667-108618372 Neighboring gene guanylate cyclase 2F, retinal Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:108715324-108715825 Neighboring gene Sharpr-MPRA regulatory region 8383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29843 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:108829413-108830382 Neighboring gene MFN1 pseudogene 1 Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer. Malone CF, et al. Cancer Discov, 2021 Sep. PMID 33883167, Free PMC Article
    2. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. Herold A, et al. Mol Cell Biol, 2000 Dec. PMID 11073998, Free PMC Article
    3. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar FJ, et al. Mol Syst Biol, 2013 Oct 8. PMID 24104479, Free PMC Article
    4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Zhang QH, et al. Genome Res, 2000 Oct. PMID 11042152, Free PMC Article
    5. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    part_of nuclear RNA export factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of nuclear RNA export factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NTF2-related export protein 2
    Names
    protein p15-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029691.1 RefSeqGene

      Range
      6064..13918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001242617.2 → NP_001229546.1  NTF2-related export protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001229546.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. This results in translation initiation from a downstream AUG, and an isoform (2, also known as p15-2a) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA806876, AF201942, BC014888, DA442845
      Consensus CDS
      CCDS56605.1
      UniProtKB/Swiss-Prot
      D3DUY1, Q0VAN8, Q5JYV5, Q5JYV6, Q5JYV7, Q9H8U0, Q9NPJ8, Q9NQ64, Q9NRL7, Q9Y3M4, Q9Y3M5
      Related
      ENSP00000361178.1, ENST00000372106.6
      Conserved Domains (1) summary
      cd00780
      Location:13 → 138
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    2. NM_001242618.2 → NP_001229547.1  NTF2-related export protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001229547.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs at the 5' end compared to variant 1. This results in translation initiation from a downstream AUG, and an isoform (3, also known as p15-2b) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA806876, AJ278323, BC014888
      Consensus CDS
      CCDS56606.1
      UniProtKB/Swiss-Prot
      Q9NPJ8
      Related
      ENSP00000361175.1, ENST00000372103.1
      Conserved Domains (1) summary
      cd00780
      Location:1 → 110
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    3. NM_018698.5 → NP_061168.2  NTF2-related export protein 2 isoform 1

      See identical proteins and their annotated locations for NP_061168.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA806876, AK023289, BC014888
      Consensus CDS
      CCDS14546.1
      UniProtKB/Swiss-Prot
      Q9NPJ8
      Related
      ENSP00000218004.1, ENST00000218004.5
      Conserved Domains (1) summary
      cd00780
      Location:68 → 193
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      109535824..109544698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530989.3 → XP_011529291.1  NTF2-related export protein 2 isoform X1

      Conserved Domains (1) summary
      cd00780
      Location:12 → 137
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    2. XM_017029648.3 → XP_016885137.1  NTF2-related export protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q9NPJ8
      Conserved Domains (1) summary
      cd00780
      Location:1 → 110
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      107983286..107992160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327399.1 → XP_054183374.1  NTF2-related export protein 2 isoform X1

    2. XM_054327400.1 → XP_054183375.1  NTF2-related export protein 2 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NPJ8.1 GenPept UniProtKB/Swiss-Prot:Q9NPJ8

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