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    PPP1R26 protein phosphatase 1 regulatory subunit 26 [ Homo sapiens (human) ]

    Gene ID: 9858, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PPP1R26provided by HGNC
    Official Full Name
    protein phosphatase 1 regulatory subunit 26provided by HGNC
    Primary source
    HGNC:HGNC:29089
    See related
    Ensembl:ENSG00000196422 MIM:614056; AllianceGenome:HGNC:29089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NRBE3; KIAA0649
    Summary
    Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 4.1), kidney (RPKM 3.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PPP1R26 in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (135479066..135488892)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (147707139..147716966)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (138371628..138380738)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 5 pseudogene 2 Neighboring gene PPP1R26 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138356815-138357468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138380833-138381544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138382256-138382966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138382967-138383677 Neighboring gene piercer of microtubule wall 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20487 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:138392753-138393377 Neighboring gene uncharacterized LOC101928525 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:138396029-138396183 Neighboring gene mitochondrial ribosomal protein S2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NRBE3 promotes metastasis of breast cancer by down-regulating E-cadherin expression. Zheng T, et al. Biochim Biophys Acta Mol Cell Res, 2018 Dec. PMID 30262434
    2. A Novel Retinoblastoma Protein (RB) E3 Ubiquitin Ligase (NRBE3) Promotes RB Degradation and Is Transcriptionally Regulated by E2F1 Transcription Factor. Wang Y, et al. J Biol Chem, 2015 Nov 20. PMID 26442585, Free PMC Article
    3. KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential. Yang L, et al. Biochem Biophys Res Commun, 2005 Sep 2. PMID 16053918
    4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. Ishikawa K, et al. DNA Res, 1998 Jun 30. PMID 9734811
    5. Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. Nakayama M, et al. Genome Res, 2002 Nov. PMID 12421765, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that up-regulation of NRBE3 is correlated with lymphatic metastasis in human breast cancer (BC) tissues. Ectopic expression of NRBE3 promotes migration and invasion in BC cells. Accordingly, its knockdown inhibits migration and invasion in BC cells and lung metastasis in vivo.
      Title: NRBE3 promotes metastasis of breast cancer by down-regulating E-cadherin expression.
    2. identified NRBE3 as a novel ubiquitin E3 ligase for RB that might play a role as a potential oncoprotein in human cancers
      Title: A Novel Retinoblastoma Protein (RB) E3 Ubiquitin Ligase (NRBE3) Promotes RB Degradation and Is Transcriptionally Regulated by E2F1 Transcription Factor.
    3. we showed that KIAA0649 mRNA is widely expressed in human multiple tissues and cell lines. We have also demonstrated that KIAA0649 has oncogenic characteristics: it enhances colony formation, allows anchorage-independent growth.
      Title: KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0649

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 26
    Names
    1A6/DRIM (down-regulated in metastasis) interacting protein
    DRIM/UTP20 interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014811.5 → NP_055626.3  protein phosphatase 1 regulatory subunit 26

      See identical proteins and their annotated locations for NP_055626.3

      Status: VALIDATED

      Source sequence(s)
      AL161452
      Consensus CDS
      CCDS6988.1
      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
      Related
      ENSP00000349274.2, ENST00000356818.7
      Conserved Domains (2) summary
      pfam15740
      Location:1 → 852
      PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
      cl26386
      Location:762 → 1040
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      135479066..135488892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424216.1 → XP_047280172.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
      Related
      ENSP00000385826.3, ENST00000401470.3

    2. XM_017015358.2 → XP_016870847.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
      Related
      ENSP00000474807.1, ENST00000605286.5
      Conserved Domains (2) summary
      pfam15740
      Location:1 → 852
      PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
      cl26386
      Location:762 → 1040
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    3. XM_017015360.3 → XP_016870849.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
      Conserved Domains (2) summary
      pfam15740
      Location:1 → 852
      PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
      cl26386
      Location:762 → 1040
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    4. XM_047424222.1 → XP_047280178.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    5. XM_017015361.3 → XP_016870850.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
      Conserved Domains (2) summary
      pfam15740
      Location:1 → 852
      PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
      cl26386
      Location:762 → 1040
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    6. XM_047424220.1 → XP_047280176.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    7. XM_047424224.1 → XP_047280180.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    8. XM_024447721.2 → XP_024303489.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
      Conserved Domains (2) summary
      pfam15740
      Location:1 → 852
      PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
      cl26386
      Location:762 → 1040
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    9. XM_047424210.1 → XP_047280166.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    10. XM_017015362.3 → XP_016870851.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
      Conserved Domains (2) summary
      pfam15740
      Location:1 → 852
      PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
      cl26386
      Location:762 → 1040
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    11. XM_005263411.3 → XP_005263468.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      See identical proteins and their annotated locations for XP_005263468.1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
      Related
      ENSP00000473820.1, ENST00000604351.5
      Conserved Domains (2) summary
      pfam15740
      Location:1 → 852
      PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
      cl26386
      Location:762 → 1040
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    12. XM_047424217.1 → XP_047280173.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    13. XM_047424223.1 → XP_047280179.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    14. XM_047424218.1 → XP_047280174.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    15. XM_047424221.1 → XP_047280177.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    16. XM_047424212.1 → XP_047280168.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    17. XM_047424219.1 → XP_047280175.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    18. XM_017015357.2 → XP_016870846.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
      Conserved Domains (2) summary
      pfam15740
      Location:1 → 852
      PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
      cl26386
      Location:762 → 1040
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    19. XM_047424213.1 → XP_047280169.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    20. XM_017015356.3 → XP_016870845.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
      Conserved Domains (2) summary
      pfam15740
      Location:1 → 852
      PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
      cl26386
      Location:762 → 1040
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    21. XM_047424214.1 → XP_047280170.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    22. XM_047424209.1 → XP_047280165.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    23. XM_047424215.1 → XP_047280171.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    24. XM_047424211.1 → XP_047280167.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    25. XM_017015355.3 → XP_016870844.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
      Conserved Domains (2) summary
      pfam15740
      Location:1 → 852
      PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
      cl26386
      Location:762 → 1040
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      147707139..147716966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364353.1 → XP_054220328.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    2. XM_054364345.1 → XP_054220320.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    3. XM_054364363.1 → XP_054220338.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    4. XM_054364359.1 → XP_054220334.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    5. XM_054364365.1 → XP_054220340.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    6. XM_054364358.1 → XP_054220333.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    7. XM_054364354.1 → XP_054220329.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    8. XM_054364356.1 → XP_054220331.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    9. XM_054364347.1 → XP_054220322.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    10. XM_054364342.1 → XP_054220317.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    11. XM_054364364.1 → XP_054220339.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    12. XM_054364361.1 → XP_054220336.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    13. XM_054364360.1 → XP_054220335.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    14. XM_054364355.1 → XP_054220330.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    15. XM_054364357.1 → XP_054220332.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    16. XM_054364349.1 → XP_054220324.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    17. XM_054364362.1 → XP_054220337.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    18. XM_054364350.1 → XP_054220325.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    19. XM_054364344.1 → XP_054220319.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    20. XM_054364351.1 → XP_054220326.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    21. XM_054364346.1 → XP_054220321.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    22. XM_054364352.1 → XP_054220327.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    23. XM_054364348.1 → XP_054220323.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

    24. XM_054364343.1 → XP_054220318.1  protein phosphatase 1 regulatory subunit 26 isoform X1

      UniProtKB/Swiss-Prot
      Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T8A7.1 GenPept UniProtKB/Swiss-Prot:Q5T8A7

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