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    Rabex-5 Rabaptin-5-associated exchange factor for Rab5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38144, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rabex-5provided by FlyBase
    Official Full Name
    Rabaptin-5-associated exchange factor for Rab5provided by FlyBase
    Primary source
    FLYBASE:FBgn0262937
    Locus tag
    Dmel_CG9139
    See related
    AllianceGenome:FB:FBgn0262937
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9139; Dmel\CG9139; Rabex5; RabGEF1
    Summary
    Enables guanyl-nucleotide exchange factor activity and ubiquitin protein ligase activity. Involved in several processes, including imaginal disc-derived wing vein specification; positive regulation of protein ubiquitination; and regulation of Rab protein signal transduction. Located in apical part of cell and endocytic vesicle. Is expressed in organism and spermatozoon. Orthologous to human RABGEF1 (RAB guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rabex-5 in Genome Data Viewer
    Location:
    61F5-61F5; 3-0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1295913..1298497)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1295913..1298497)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene triforce Neighboring gene uncharacterized protein Neighboring gene supercoiling factor Neighboring gene Rac1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development. Reimels TA, et al. PLoS One, 2024. PMID 39466792, Free PMC Article
    2. Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons. Carney DS, et al. Trends Cell Biol, 2006 Jan. PMID 16330212
    3. A conserved, N-terminal tyrosine signal directs Ras for inhibition by Rabex-5. Washington C, et al. PLoS Genet, 2020 Jun. PMID 32559233, Free PMC Article
    4. Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila. Yan H, et al. Curr Biol, 2010 Aug 10. PMID 20655224, Free PMC Article
    5. A direct and functional interaction between Go and Rab5 during G protein-coupled receptor signaling. Purvanov V, et al. Sci Signal, 2010 Aug 24. PMID 20736485

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development.
      Title: Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development.
    2. Rabex-5 plays an important role in Drosophila hematopoiesis and might serve as an axis coordinating Ras and Notch signaling in the lymph gland.
      Title: Drosophila Rabex-5 restricts Notch activity in hematopoietic cells and maintains hematopoietic homeostasis.
    3. this study finds that several functions of Rabaptin-5 are conserved in Drosophila, including its GTP-dependent binding of Rab5,itsability to modulate endosomal dynamics and its interaction with Rabex- 5.
      Title: Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster.
    4. Rabex-5(CG9139) restricts Ras signaling to establish organism size, wing vein pattern, and eye versus antennal fate
      Title: Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in eye-antennal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of Rab protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of Rab protein signal transduction ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rabaptin-5-associated exchange factor for Rab5
    Names
    CG9139-PA
    Rabaptin-5-associated exchange factor for Rab5 ortholog
    Rabex-5-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1295913..1298497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138249.3 → NP_612093.1  Rabaptin-5-associated exchange factor for Rab5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612093.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0H9
      Related
      FBpp0072557
      Conserved Domains (2) summary
      pfam01754
      Location:17 → 40
      zf-A20; A20-like zinc finger
      pfam02204
      Location:274 → 373
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0H9 Q9W0H9

    Gene LinkOut

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