cathD cathepsin D [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cathDprovided by FlyBase
Official Full Name: cathepsin Dprovided by FlyBase
Primary source: FLYBASE:FBgn0029093
Locus tag: Dmel_CG1548
See related: AllianceGenome:FB:FBgn0029093
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CATH; CathD; CG1548; CG17134; CT3996; CTSD; Dmel\CG1548; T17
Summary: Predicted to enable aspartic-type endopeptidase activity. Involved in defense response to Gram-negative bacterium and nurse cell apoptotic process. Located in lysosome. Is expressed in several structures, including adult head; adult heart; epithelium; head epidermis primordium; and mesoderm. Used to study neuronal ceroid lipofuscinosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (cathepsin D). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 43E18-43E18; 2-57 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7815339..7823569, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3709616..3711074, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ca2+ administration prevents alpha-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis.
Title: Ca2+ administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis.
Lysosomal Hydrolase Cathepsin D Non-proteolytically Modulates Dendritic Morphology in Drosophila.
Title: Lysosomal Hydrolase Cathepsin D Non-proteolytically Modulates Dendritic Morphology in Drosophila.
Depletion or null mutation of Rab6 led to a loss of Cathepsin D targeting to lysosome.
Title: Rab6 promotes insulin receptor and cathepsin trafficking to regulate autophagy induction and activity in Drosophila.
Changes in Drosophila mitochondrial proteins following chaperone-mediated lifespan extension confirm a role of Hsp22 in mitochondrial UPR and reveal a mitochondrial localization for cathepsin D
Title: Changes in Drosophila mitochondrial proteins following chaperone-mediated lifespan extension confirm a role of Hsp22 in mitochondrial UPR and reveal a mitochondrial localization for cathepsin D.
The metabolic pathway leading to neuronal ceroid lipofuscinosis (NCL) pathology is highly conserved during evolution, as demonstrated by this model using cathepsin D mutant flies that exhibit key features of NCLs.
Title: Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nurse cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	HDA more info	PubMed
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cathepsin D

Names: CG1548-PA; CG1548-PB; CG1548-PC; Cathepsin-D; CathepsinD; cathD-PA; cathD-PB; cathD-PC

NP_001334713.1

EC 3.4.23.-

NP_001334714.1

EC 3.4.23.-

NP_652013.1

EC 3.4.23.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

7815339..7823569 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001347753.1 → NP_001334714.1 cathepsin D, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7K485
NM_001347752.1 → NP_001334713.1 cathepsin D, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7K485
NM_143756.3 → NP_652013.1 cathepsin D, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_652013.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K485

Related

FBpp0087972

Conserved Domains (3) summary

pfam00026
Location:72 → 391

Asp; Eukaryotic aspartyl protease

pfam07966
Location:27 → 53

A1_Propeptide; A1 Propeptide

cl11403
Location:62 → 389

pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases