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    Gmap Golgi microtubule-associated protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32483, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gmapprovided by FlyBase
    Official Full Name
    Golgi microtubule-associated proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027287
    Locus tag
    Dmel_CG33206
    See related
    AllianceGenome:FB:FBgn0027287
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32587; CG33206; CG6350; CG7821; dGMAP; Dmel\CG33206; GMAP; GMAP-210; GMAP210; l(1)G0168
    Summary
    Enables cargo receptor activity and small GTPase binding activity. Involved in Golgi organization; intra-Golgi vesicle-mediated transport; and vesicle tethering to Golgi. Located in Golgi cis cisterna and Golgi membrane. Is active in cis-Golgi network membrane. Is expressed in several structures, including cercus; embryonic ocular segment; embryonic/larval gut; epithelium; and gut section. Human ortholog(s) of this gene implicated in achondrogenesis type IA. Orthologous to human TRIP11 (thyroid hormone receptor interactor 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Gmap in Genome Data Viewer
    Location:
    13C5-13C7; 1-50 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15486922..15511223)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15380955..15405256)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44888 Neighboring gene mir-283 stem loop Neighboring gene mir-304 stem loop Neighboring gene mir-12 stem loop Neighboring gene Adenylyl cyclase 13E Neighboring gene long non-coding RNA:CR44353 Neighboring gene long non-coding RNA:CR44354 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cis-Golgi Drosophila GMAP has a role in anterograde transport and Golgi organization in vivo, similar to its mammalian ortholog in tissue culture cells. Friggi-Grelin F, et al. Eur J Cell Biol, 2006 Nov. PMID 16904228
    2. In vivo characterization of Drosophila golgins reveals redundancy and plasticity of vesicle capture at the Golgi apparatus. Park SY, et al. Curr Biol, 2022 Nov 7. PMID 36103876, Free PMC Article
    3. An antibody toolkit for the study of membrane traffic in Drosophila melanogaster. Riedel F, et al. Biol Open, 2016 Jul 15. PMID 27256406, Free PMC Article
    4. Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. Vacaru AM, et al. J Cell Biol, 2009 Jun 15. PMID 19506037, Free PMC Article
    5. GM130 is required for compartmental organization of dendritic golgi outposts. Zhou W, et al. Curr Biol, 2014 Jun 2. PMID 24835455, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the dGMAP gene encodes two alternatively spliced transcripts, only one of which is translated into a protein product. dGMAP is the ortholog of mammalian GMAP-210, and has a role in anterograde transport and Golgi apparatus
      Title: The cis-Golgi Drosophila GMAP has a role in anterograde transport and Golgi organization in vivo, similar to its mammalian ortholog in tissue culture cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cargo receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle tethering to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cis-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    golgi microtubule-associated protein
    Names
    CG33206-PA
    CG33206-PB
    CG33206-PC
    CG33206-PD
    Gmap-PA
    Gmap-PB
    Gmap-PC
    Gmap-PD
    golgi microtuble Assoc. Prot, C
    lethal (1) G0168

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15486922..15511223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001370008.1 → NP_001356946.1  golgi microtubule-associated protein, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K5M0
      Conserved Domains (2) summary
      COG1196
      Location:161 → 983
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:799 → 1185
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. NM_176734.2 → NP_788907.1  golgi microtubule-associated protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960D0, Q9VXU2
      Related
      FBpp0073859
      Conserved Domains (3) summary
      COG1196
      Location:158 → 906
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09728
      Location:716 → 987
      Taxilin; Myosin-like coiled-coil protein
      cl19219
      Location:645 → 761
      DUF342; Protein of unknown function (DUF342)

    3. NM_001298345.1 → NP_001285274.1  golgi microtubule-associated protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285274.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXU1
      Conserved Domains (2) summary
      COG1196
      Location:34 → 793
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19219
      Location:455 → 571
      DUF342; Protein of unknown function (DUF342)

    4. NM_176735.3 → NP_788908.1  golgi microtubule-associated protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788908.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXU1
      Related
      FBpp0073860
      Conserved Domains (2) summary
      COG1196
      Location:34 → 793
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19219
      Location:455 → 571
      DUF342; Protein of unknown function (DUF342)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4D6K5M0 A0A4D6K5M0
    Q9VXU1 Q9VXU1
    Q9VXU2 Q9VXU2

    Gene LinkOut

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