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    Uba2 Ubiquitin-like activating enzyme 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44496, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uba2provided by FlyBase
    Official Full Name
    Ubiquitin-like activating enzyme 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0029113
    Locus tag
    Dmel_CG7528
    See related
    AllianceGenome:FB:FBgn0029113
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7528; Dmel\CG7528; DmSae2; DmSAE2; Dmuba2; DmUba2; dUba2; L36; Sae2; SAE2; sip2; uba2; UBA2; Ubc2
    Summary
    Enables ubiquitin activating enzyme binding activity. Contributes to SUMO activating enzyme activity. Involved in several processes, including positive regulation of antimicrobial peptide production; protein sumoylation; and regulation of signal transduction. Located in cytoplasm and nucleus. Is expressed in several structures, including central brain primordium; embryonic/larval midgut primordium; ganglia; germline cell; and mesoderm. Used to study hematologic cancer. Orthologous to human UBA2 (ubiquitin like modifier activating enzyme 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Uba2 in Genome Data Viewer
    Location:
    66B7-66B7; 3-22 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8125327..8127818, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8118427..8120918, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene lariat debranching enzyme Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L36 Neighboring gene CDP-diacylglycerol synthase Neighboring gene Senataxin Neighboring gene mutagen-sensitive 301 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterisation of the Drosophila homologue of the yeast Uba2 gene. Donaghue C, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267682
    2. Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila. Chan HY, et al. Hum Mol Genet, 2002 Nov 1. PMID 12393801
    3. Sumoylation is tumor-suppressive and confers proliferative quiescence to hematopoietic progenitors in Drosophila melanogaster larvae. Kalamarz ME, et al. Biol Open, 2012 Mar 15. PMID 23213407, Free PMC Article
    4. Expression of genes involved in sumoylation in the Drosophila germline. Hashiyama K, et al. Gene Expr Patterns, 2009 Jan. PMID 18755298
    5. Identification and characterization of a SUMO-1 conjugation system that modifies neuronal calcium/calmodulin-dependent protein kinase II in Drosophila melanogaster. Long X, et al. J Biol Chem, 2000 Dec 29. PMID 10995744

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to SUMO activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SUMO activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin activating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of negative regulation melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Toll signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SUMO activating enzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ubiquitin-like activating enzyme 2
    Names
    CG7528-PA
    Smt3 activating enzyme 2
    Smt3-activating enzyme 2
    Uba2-PA
    ubiquitin activating enzyme 2
    ubiquitin-activating enzyme (E1)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8125327..8127818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080017.3 → NP_524756.2  Ubiquitin-like activating enzyme 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524756.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KJV6, Q7KUA4
      Related
      FBpp0076457
      Conserved Domains (4) summary
      cd01489
      Location:21 → 459
      Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
      pfam00899
      Location:7 → 177
      ThiF; ThiF family
      pfam14732
      Location:467 → 552
      UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
      pfam16195
      Location:573 → 691
      UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KJV6 Q7KJV6
    Q7KUA4 Q7KUA4
    Q9VSD9 Q9VSD9

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