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    Dph3 Diphthamide biosynthesis 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41352, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dph3provided by FlyBase
    Official Full Name
    Diphthamide biosynthesis 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0037883
    Locus tag
    Dmel_CG14701
    See related
    AllianceGenome:FB:FBgn0037883
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14701; Dmel\CG14701; Kti11
    Summary
    Predicted to enable ferrous iron binding activity and iron chaperone activity. Predicted to be involved in protein histidyl modification to diphthamide and tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation. Predicted to be located in cytoplasm and nucleus. Is expressed in organism. Orthologous to human DPH3 (diphthamide biosynthesis 3) and DPH3P1 (diphthamide biosynthesis 3 pseudogene 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dph3 in Genome Data Viewer
    Location:
    86D8-86D8; 3-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11231912..11232539)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7057634..7058261)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene GRIP and coiled-coil domain containing 88 kDa Neighboring gene uncharacterized protein Neighboring gene Arfaptin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion. Cinà DP, et al. Am J Physiol Renal Physiol, 2019 Dec 1. PMID 31566424, Free PMC Article
    2. Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants. Planelles-Herrero VJ, et al. Nat Cell Biol, 2022 Nov. PMID 36302967, Free PMC Article
    3. Definition of global and transcript-specific mRNA export pathways in metazoans. Farny NG, et al. Genes Dev, 2008 Jan 1. PMID 18086857, Free PMC Article
    4. Ultra-deep sequencing of ribosome-associated poly-adenylated RNA in early Drosophila embryos reveals hundreds of conserved translated sORFs. Li H, et al. DNA Res, 2016 Dec. PMID 27559081, Free PMC Article
    5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ferrous iron binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron chaperone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein histidyl modification to diphthamide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    diphthamide biosynthesis 3
    Names
    CG14701-PA
    Dph3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11231912..11232539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141800.2 → NP_650057.1  diphthamide biosynthesis 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650057.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4QPS1, Q9VGQ9
      Related
      FBpp0081829
      Conserved Domains (1) summary
      pfam05207
      Location:25 → 60
      zf-CSL; CSL zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGQ9.1 Q9VGQ9

    Gene LinkOut

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