Nup98-96 Nucleoporin 98-96kD [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nup98-96provided by FlyBase
Official Full Name: Nucleoporin 98-96kDprovided by FlyBase
Primary source: FLYBASE:FBgn0039120
Locus tag: Dmel_CG10198
See related: AllianceGenome:FB:FBgn0039120
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10198; CG10201; Dmel\CG10198; l(3)95BCd; Nup; Nup 96; Nup 98; Nup-98; nup145; Nup96; Nup96-98; nup98; Nup98; NUP98; nup98-96; Nup98-Nup96; NUP98-NUP96; Nup98/96
Summary: Enables promoter-enhancer loop anchoring activity and promoter-specific chromatin binding activity. Involved in several processes, including heat shock-mediated polytene chromosome puffing; nucleocytoplasmic transport; and positive regulation of macromolecule biosynthetic process. Located in chromosome; cytoplasm; and nucleus. Part of nuclear pore. Is expressed in adult head; cyst progenitor cell; and male germline stem cell. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Orthologous to human NUP98 (nucleoporin 98 and 96 precursor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 95B1-95B5; 3-80 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23774225..23781621, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19599947..19607343, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene.
Title: A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene.
The distribution of Moesin in the nucleus suggests a function in transcription and the depletion of mRNA export factors Nup98 or its interacting partner, Rae1, leads to the nuclear accumulation of Moesin, suggesting that the nuclear function of the protein is linked to mRNA export
Title: The actin binding cytoskeletal protein Moesin is involved in nuclear mRNA export.
Nup98 provides a scaffold for poised genes and mediates Induced enhancer-promoter contacts in genetic transcription.
Title: Metazoan Nuclear Pores Provide a Scaffold for Poised Genes and Mediate Induced Enhancer-Promoter Contacts.
Nup98 associates and colocalizes with the MBD-R2/NSL and Trx complexes. Nup98 regulates transcription of Trx targets, the Hox genes.
Title: Nucleoporin Nup98 associates with Trx/MLL and NSL histone-modifying complexes and regulates Hox gene expression.
Nup98, a virus-induced gene, was antiviral against a panel of viruses.
Title: Nup98 promotes antiviral gene expression to restrict RNA viral infection in Drosophila.
Nup88 localizes to silent loci, Sec13, Nup98, and a subset of FG-repeat nucleoporins bind to developmentally regulated genes undergoing transcription induction.
Title: Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes.
Study analyzed genomic interactions of full-length nucleoporins Nup98, Nup50, and Nup62 and found that they predominantly interacted with active genes inside the nucleoplasm, particularly those involved in developmental regulation and the cell cycle.
Title: Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm.
causes epistatic inviability in hybrids between two fruitfly species, Drosophila melanogaster and D. simulans
Title: Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables promoter-enhancer loop anchoring activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine hydrolase activity	HDA more info	PubMed
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info
enables structural constituent of nuclear pore	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to ecdysone	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heat shock-mediated polytene chromosome puffing	IDA Inferred from Direct Assay more info	PubMed
involved_in larval lymph gland hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation by host of viral transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nucleocytoplasmic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ecdysone	IDA Inferred from Direct Assay more info	PubMed
involved_in telomere tethering at nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IPI Inferred from Physical Interaction more info	PubMed
part_of nuclear pore central transport channel	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear pore cytoplasmic filaments	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome band	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: nucleoporin 98-96kD

Names: CG10198-PA; CG10198-PC; CG10198-PD; Nup98; Nup98-96-PA; Nup98-96-PC; Nup98-96-PD; nucleoporin 96; nucleoporin 98; nucleoporin 98-96; nucleoporin98-96

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

23774225..23781621 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_142930.3 → NP_651187.2 nucleoporin 98-96kD, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651187.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B8A421, Q6NP55, Q9VCH5

Conserved Domains (4) summary

pfam04096
Location:888 → 1027

Nucleoporin2; Nucleoporin autopeptidase

pfam12110
Location:1484 → 1762

Nup96; Nuclear protein 96

pfam13634
Location:50 → 164

Nucleoporin_FG; Nucleoporin FG repeat region

pfam16768
Location:316 → 522

NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
NM_001275956.1 → NP_001262885.1 nucleoporin 98-96kD, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262885.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B8A421, Q6NP55, Q9VCH5

Conserved Domains (4) summary

pfam04096
Location:888 → 1027

Nucleoporin2; Nucleoporin autopeptidase

pfam12110
Location:1484 → 1762

Nup96; Nuclear protein 96

pfam13634
Location:50 → 164

Nucleoporin_FG; Nucleoporin FG repeat region

pfam16768
Location:316 → 522

NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
NM_001260337.1 → NP_001247266.1 nucleoporin 98-96kD, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247266.1

Status: REVIEWED

Conserved Domains (2) summary

pfam04096
Location:888 → 1028

Nucleoporin2; Nucleoporin autopeptidase

pfam13634
Location:83 → 177

Nucleoporin_FG; Nucleoporin FG repeat region

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A1YK24		A1YK24
A1YK25		A1YK25
A1YK27		A1YK27
A1YK33		A1YK33
A1YK35		A1YK35
A1YK36		A1YK36
A1YK38		A1YK38
Q867H5		Q867H5
Q867M2		Q867M2
Q867M7		Q867M7
Q867W7		Q867W7
Q868A8		Q868A8
Q86G43		Q86G43
Q9VCH5.3		Q9VCH5