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    Capr Caprin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 59172, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Caprprovided by FlyBase
    Official Full Name
    Caprinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0042134
    Locus tag
    Dmel_CG18811
    See related
    AllianceGenome:FB:FBgn0042134
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.253; capr; CG18811; dCaprin; dFAP; Dmel\CG18811; NEST:bs19b07
    Summary
    Enables RNA binding activity. Involved in cellularization and regulation of mitotic cell cycle, embryonic. Located in cytoplasm. Part of ribonucleoprotein complex. Is expressed in several structures, including adult brain cell body rind; adult gnathal ganglion; female germline stem cell; ovary; and somatic cell of ovariole. Orthologous to several human genes including CAPRIN1 (cell cycle associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Capr in Genome Data Viewer
    Location:
    75D5-75D6; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18668153..18673324, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18661253..18666424, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Myosin phosphatase targeting subunit 75D Neighboring gene uncharacterized protein Neighboring gene Gram-negative bacteria binding protein 2 Neighboring gene Gram-negative bacteria binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of a 123 amino acids dimerization domain of Drosophila Caprin. Zhu J, et al. Proteins, 2020 Dec. PMID 32725918, Free PMC Article
    2. Crystal structure of a dimerization domain of human Caprin-2: similar overall dimeric fold but different molecular surface properties to that of human Caprin-1. Wu Y, et al. J Biomol Struct Dyn, 2019 Sep. PMID 30304999, Free PMC Article
    3. Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation. Aguilera-Gomez A, et al. Cell Rep, 2017 Jul 25. PMID 28746877, Free PMC Article
    4. The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway. Costa A, et al. Dev Cell, 2005 Mar. PMID 15737929
    5. Caprin controls follicle stem cell fate in the Drosophila ovary. Reich J, et al. PLoS One, 2012. PMID 22493746, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lig regulates cell proliferation during development in concert with Rin, Capr and FMR1.
      Title: The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster.
    2. misregulation of CycB contributes to the disruption in behavior of follicle stem cell progeny.
      Title: Caprin controls follicle stem cell fate in the Drosophila ovary.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellularization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle, embryonic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    caprin
    Names
    CG18811-PA
    CG18811-PB
    Capr-PA
    Capr-PB
    dFMRP-associated protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18668153..18673324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300178.1 → NP_001287107.1  caprin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287107.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9I7D3
      UniProtKB/TrEMBL
      E4NKG1
      Conserved Domains (2) summary
      PRK12704
      Location:109 → 199
      PRK12704; phosphodiesterase; Provisional
      pfam18293
      Location:187 → 305
      Caprin-1_dimer; Caprin-1 dimerization domain

    2. NM_144414.2 → NP_652671.1  caprin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652671.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9I7D3
      UniProtKB/TrEMBL
      E4NKG1
      Related
      FBpp0074865
      Conserved Domains (2) summary
      PRK12704
      Location:109 → 199
      PRK12704; phosphodiesterase; Provisional
      pfam18293
      Location:187 → 305
      Caprin-1_dimer; Caprin-1 dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E4NKG1 E4NKG1
    Q9I7D3.1 Q9I7D3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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