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    VhaPPA1-1 Vacuolar H[+] ATPase PPA1 subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45247, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VhaPPA1-1provided by FlyBase
    Official Full Name
    Vacuolar H[+] ATPase PPA1 subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0028662
    Locus tag
    Dmel_CG7007
    See related
    AllianceGenome:FB:FBgn0028662
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7007; Dmel\CG7007; V0c''; Vha26; VhaPPA1; vhaPPA1-1
    Summary
    Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Involved in terminal branching, open tracheal system. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in adult Malpighian tubule; adult head; and testis. Orthologous to human ATP6V0B (ATPase H+ transporting V0 subunit b). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See VhaPPA1-1 in Genome Data Viewer
    Location:
    88D6-88D6; 3-56 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14902330..14904061, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10728052..10729783, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase PPA1 subunit 2 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S5b Neighboring gene long non-coding RNA:CR46199 Neighboring gene Secreted decoy of InR

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo. Terrasi A, et al. EBioMedicine, 2019 Mar. PMID 30737087, Free PMC Article
    2. Discovery of insect and human dengue virus host factors. Sessions OM, et al. Nature, 2009 Apr 23. PMID 19396146, Free PMC Article
    3. Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB. Wang Y, et al. EMBO Rep, 2020 Jan 7. PMID 31750630, Free PMC Article
    4. Compensatory branching morphogenesis of stalk cells in the Drosophila trachea. Francis D, et al. Development, 2015 Jun 1. PMID 25977367, Free PMC Article
    5. Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster. Tognon E, et al. Autophagy, 2016. PMID 26727288, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to proton-transporting ATPase activity, rotational mechanism IC
    Inferred by Curator
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in terminal branching, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of plasma membrane proton-transporting V-type ATPase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar H[+] ATPase PPA1 subunit 1
    Names
    CG7007-PA
    CG7007-PB
    V-ATPase proton pump
    VhaPPA1-1-PA
    VhaPPA1-1-PB
    vacuolar H[+] ATPase subunit PPA1-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14902330..14904061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260182.2 → NP_001247111.1  vacuolar H[+] ATPase PPA1 subunit 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247111.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFE3
      Conserved Domains (2) summary
      cd18177
      Location:51 → 113
      ATP-synt_Vo_c_ATP6F_rpt1; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins
      cd18178
      Location:138 → 202
      ATP-synt_Vo_c_ATP6F_rpt2; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins

    2. NM_143753.2 → NP_652010.1  vacuolar H[+] ATPase PPA1 subunit 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652010.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFE3
      Related
      FBpp0082464
      Conserved Domains (2) summary
      cd18177
      Location:51 → 113
      ATP-synt_Vo_c_ATP6F_rpt1; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins
      cd18178
      Location:138 → 202
      ATP-synt_Vo_c_ATP6F_rpt2; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFE3 Q9VFE3

    Gene LinkOut

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