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    RhoGAP71E Rho GTPase activating protein at 71E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RhoGAP71Eprovided by FlyBase
    Official Full Name
    Rho GTPase activating protein at 71Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036518
    Locus tag
    Dmel_CG32149
    See related
    AllianceGenome:FB:FBgn0036518
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD07615; C- GAP; C-GAP; CG16980; CG32149; CG7396; Dmel\CG32149; l(3)j6B9; RhoGAP-71E1; rhogap71e; RhoGap71E; RoGAP71E
    Summary
    Enables GTPase activator activity. Involved in apical constriction involved in gastrulation and imaginal disc-derived leg morphogenesis. Located in apical part of cell. Is expressed in several structures, including CNS glial cell; epithelial furrow; ganglia; head epidermis primordium; and mesoderm. Orthologous to human ARHGAP20 (Rho GTPase activating protein 20). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RhoGAP71E in Genome Data Viewer
    Location:
    71E1-71E2; 3-43 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15588860..15609125)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15581960..15602225)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene aaRS-interacting multifunctional protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene comm3 Neighboring gene Phaser

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue flows are tuned by actomyosin-dependent mechanics in developing embryos. Herrera-Perez RM, et al. PRX Life, 2023 Jul-Sep. PMID 38736460, Free PMC Article
    2. Using optogenetics to link myosin patterns to contractile cell behaviors during convergent extension. Herrera-Perez RM, et al. Biophys J, 2021 Oct 5. PMID 34293302, Free PMC Article
    3. RhoA GTPase inhibition organizes contraction during epithelial morphogenesis. Mason FM, et al. J Cell Biol, 2016 Aug 29. PMID 27551058, Free PMC Article
    4. Medioapical contractile pulses coordinated between cells regulate Drosophila eye morphogenesis. Rosa-Birriel C, et al. J Cell Biol, 2024 Feb 5. PMID 38126997, Free PMC Article
    5. Combinatorial patterns of graded RhoA activation and uniform F-actin depletion promote tissue curvature. Denk-Lobnig M, et al. Development, 2021 Jun 1. PMID 34124762, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in apical constriction involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rho GTPase activating protein at 71E
    Names
    CG32149-PA
    CG32149-PB
    CG32149-PC
    CG32149-PD
    CG32149-PE
    CG32149-PF
    CG32149-PG
    Cumberland-GAP
    RhoGAP71E-PA
    RhoGAP71E-PB
    RhoGAP71E-PC
    RhoGAP71E-PD
    RhoGAP71E-PE
    RhoGAP71E-PF
    RhoGAP71E-PG
    cumberland GAP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15588860..15609125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144484.3 → NP_001137956.1  Rho GTPase activating protein at 71E, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137956.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z058
      Conserved Domains (1) summary
      cd00159
      Location:55 → 228
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    2. NM_168629.4 → NP_730060.1  Rho GTPase activating protein at 71E, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUR6
      Related
      FBpp0075322
      Conserved Domains (1) summary
      cd00159
      Location:55 → 228
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    3. NM_001202183.2 → NP_001189112.1  Rho GTPase activating protein at 71E, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189112.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRW2
      Conserved Domains (1) summary
      cd00159
      Location:55 → 228
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    4. NM_001274957.1 → NP_001261886.1  Rho GTPase activating protein at 71E, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261886.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFR0
      Conserved Domains (1) summary
      cd00159
      Location:55 → 228
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    5. NM_001274958.1 → NP_001261887.1  Rho GTPase activating protein at 71E, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFL1
      Conserved Domains (1) summary
      cd00159
      Location:55 → 228
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    6. NM_140527.5 → NP_648784.1  Rho GTPase activating protein at 71E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RX4, Q9VUR5
      Related
      FBpp0075321
      Conserved Domains (1) summary
      cd00159
      Location:55 → 228
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    7. NM_168630.4 → NP_730061.1  Rho GTPase activating protein at 71E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730061.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQM3
      Related
      FBpp0075320
      Conserved Domains (1) summary
      cd00159
      Location:55 → 228
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z058 B7Z058
    M9MRW2 M9MRW2
    M9PFL1 M9PFL1
    M9PFR0 M9PFR0
    Q8IQM3 Q8IQM3
    Q8SZI4 Q8SZI4
    Q9VUR5 Q9VUR5
    Q9VUR6 Q9VUR6

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