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    Unc-76 Uncoordinated 76 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31179, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Unc-76provided by FlyBase
    Official Full Name
    Uncoordinated 76provided by FlyBase
    Primary source
    FLYBASE:FBgn0040395
    Locus tag
    Dmel_CG3981
    See related
    AllianceGenome:FB:FBgn0040395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH10260; CG18851; CG3981; Dmel\CG3981; Dunc-76; EG:67A9.1; l(1)G0066; l(1)G0158; l(1)G0310; l(1)G0333; l(1)G0360; unc-76; UNC-76; unc76
    Summary
    Enables kinesin binding activity. Involved in axo-dendritic transport. Predicted to be active in axon and cytoplasm. Is expressed in larval longitudinal connective; larval segmental nerve; larval ventral nerve cord commissure; and presumptive embryonic/larval central nervous system. Used to study Jacobsen Syndrome. Orthologous to several human genes including FEZ1 (fasciculation and elongation protein zeta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Unc-76 in Genome Data Viewer
    Location:
    2C10-2D1; 1-0.6 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2080610..2093948)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1974643..1987981)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene RNA 3'-terminal phosphate cyclase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene corkscrew Neighboring gene polyhomeotic distal

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Screens in fly and beetle reveal vastly divergent gene sets required for developmental processes. Hakeemi MS, et al. BMC Biol, 2022 Feb 8. PMID 35135533, Free PMC Article
    2. Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development. Gunaseelan S, et al. Hum Mol Genet, 2021 Mar 25. PMID 33395696
    3. The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system. Gindhart JG, et al. Mol Biol Cell, 2003 Aug. PMID 12925768, Free PMC Article
    4. Role of kinesin-1-based microtubule sliding in Drosophila nervous system development. Winding M, et al. Proc Natl Acad Sci U S A, 2016 Aug 23. PMID 27512046, Free PMC Article
    5. A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones. Siebert M, et al. Elife, 2015 Aug 14. PMID 26274777, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.
      Title: Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.
    2. UNC-76 is required for kinesin-dependent axonal transport
      Title: The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables kinesin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axo-dendritic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncoordinated 76
    Names
    CG3981-PA
    CG3981-PB
    CG3981-PC
    CG3981-PD
    Unc-76-PA
    Unc-76-PB
    Unc-76-PC
    Unc-76-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2080610..2093948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272243.1 → NP_001259172.1  uncoordinated 76, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259172.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0E2, Q9TVM9, Q9W525
      Conserved Domains (1) summary
      pfam07763
      Location:143 → 418
      FEZ; FEZ-like protein

    2. NM_130625.3 → NP_569981.1  uncoordinated 76, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569981.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0E2, Q9TVM9, Q9W525
      Related
      FBpp0070360
      Conserved Domains (1) summary
      pfam07763
      Location:143 → 418
      FEZ; FEZ-like protein

    3. NM_166927.2 → NP_726792.1  uncoordinated 76, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726792.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0E2, Q9TVM9, Q9W525
      Related
      FBpp0070361
      Conserved Domains (1) summary
      pfam07763
      Location:143 → 418
      FEZ; FEZ-like protein

    4. NM_001272244.1 → NP_001259173.1  uncoordinated 76, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259173.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGS9
      Conserved Domains (1) summary
      pfam07763
      Location:1 → 233
      FEZ; FEZ-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGS9 M9PGS9
    Q8T0S7 Q8T0S7
    Q9TVM9 Q9TVM9
    Q9W525 Q9W525

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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