CG4598 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG4598provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0032160
Locus tag: Dmel_CG4598
See related: AllianceGenome:FB:FBgn0032160
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Dmel\CG4598
Summary: Predicted to enable delta(3)-delta(2)-enoyl-CoA isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Is expressed in adult head and adult heart. Orthologous to human ECI1 (enoyl-CoA delta isomerase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 30E4-30E4; 2-37 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9918618..9920120)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9918618..9920120)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG4598-PA; CG4598-PB

NP_001260304.1

EC 5.3.3.8

NP_609322.1

EC 5.3.3.8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

9918618..9920120

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273375.1 → NP_001260304.1 uncharacterized protein Dmel_CG4598, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260304.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VL68

Conserved Domains (1) summary

cd06558
Location:27 → 217

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
NM_135478.3 → NP_609322.1 uncharacterized protein Dmel_CG4598, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609322.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VL68

Related

FBpp0079473

Conserved Domains (1) summary

cd06558
Location:27 → 217

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...