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    Pdk1 Phosphoinositide-dependent kinase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38017, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pdk1provided by FlyBase
    Official Full Name
    Phosphoinositide-dependent kinase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0020386
    Locus tag
    Dmel_CG1210
    See related
    AllianceGenome:FB:FBgn0020386
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1210; CG1201; CG1210; Dmel\CG1210; dPDK; dPDK-1; dPdk1; dPDK1; dSTPK61; Dstpk61; DSTPK61; PDK; PDK-1; pdk1; PDK1; PDK1/Pk61C; pdpk1; Pdpk1; pk61c; Pk61C; PK61C; Pk61c/PDK1; Pk61C/PDK1
    Summary
    Enables 3-phosphoinositide-dependent protein kinase activity and protein kinase activator activity. Involved in several processes, including insulin receptor signaling pathway; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of cell size. Located in neuromuscular junction. Is expressed in several structures, including adult brain cell body rind; central brain anlage; central brain primordium; embryonic dorsal epidermis; and embryonic head epidermis. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pdk1 in Genome Data Viewer
    Location:
    61B1-61B1; 3-1 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (129450..145895)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (129450..145895)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45402 Neighboring gene long non-coding RNA:CR45400 Neighboring gene long non-coding RNA:CR45805 Neighboring gene uncharacterized protein Neighboring gene Dynein intermediate chain at 61B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Dstpk61 locus of Drosophila produces multiple transcripts and protein isoforms, suggesting it is involved in multiple signalling pathways. Clyde D, et al. J Endocrinol, 2000 Dec. PMID 11115766
    2. Sex-specific transcripts of the Dstpk61 serine/threonine kinase gene in Drosophila melanogaster. MacDougall CN, et al. Eur J Biochem, 1999 Jun. PMID 10336630
    3. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Coffer PJ, et al. Biochem J, 1998 Oct 1. PMID 9742206, Free PMC Article
    4. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Stephens L, et al. Science, 1998 Jan 30. PMID 9445477
    5. Drosophila, a powerful model to study virus-host interactions and pathogenicity in the fight against SARS-CoV-2. van de Leemput J, et al. Cell Biosci, 2021 Jun 13. PMID 34120640, Free PMC Article

    See all (229) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK.
      Title: Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK.
    2. The authors show that loss of frataxin homolog (fh) in Drosophila leads to iron toxicity, which in turn induces sphingolipid synthesis and ectopically activates 3-phosphoinositide dependent protein kinase-1 (Pdk1) and myocyte enhancer factor-2 (Mef2).
      Title: Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration.
    3. PDK1 is also a presynaptic protein, though it is distributed more broadly.
      Title: S6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse development.
    4. dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase 1, dPDK1
      Title: dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC1 signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasmic side of plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Phosphoinositide-dependent kinase 1
    Names
    CG1210-PA
    CG1210-PB
    CG1210-PC
    CG1210-PD
    CG1210-PE
    CG1210-PF
    CG1210-PG
    CG1210-PH
    CG1210-PJ
    Pdk1-PA
    Pdk1-PB
    Pdk1-PC
    Pdk1-PD
    Pdk1-PE
    Pdk1-PF
    Pdk1-PG
    Pdk1-PH
    Pdk1-PJ
    phosphoinositide dependent kinase 1
    phosphoinositide-dependent kinase 1
    pk61c
    protein kinase 61C
    serine/threonine protein kinase
    NP_001261183.1
    NP_525121.2
    NP_728470.1
    NP_728471.2
    NP_728472.1
    NP_728473.1
    NP_728474.1
    NP_728475.1
    NP_728476.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      129450..145895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274254.1 → NP_001261183.1  Phosphoinositide-dependent kinase 1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261183.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62534, Q0E8K9, Q53XF5, Q7KVE1, Q8IHG6, Q9W0V1, Q9W0V2, Q9W0V3
      UniProtKB/TrEMBL
      C7LAC8, H5V8B9
      Conserved Domains (3) summary
      smart00220
      Location:246 → 571
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:658 → 764
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:244 → 571
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

    2. NM_167790.3 → NP_728471.2  Phosphoinositide-dependent kinase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728471.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62534, Q0E8K9, Q53XF5, Q7KVE1, Q8IHG6, Q9W0V1, Q9W0V2, Q9W0V3
      UniProtKB/TrEMBL
      C7LAC8, H5V8B9
      Related
      FBpp0072366
      Conserved Domains (3) summary
      smart00220
      Location:246 → 571
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:658 → 764
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:244 → 571
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

    3. NM_167791.3 → NP_728472.1  Phosphoinositide-dependent kinase 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728472.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V164, C7LAC8
      Related
      FBpp0072369
      Conserved Domains (3) summary
      smart00220
      Location:165 → 490
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:577 → 683
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:163 → 490
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

    4. NM_167792.3 → NP_728473.1  Phosphoinositide-dependent kinase 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728473.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V164, C7LAC8
      Related
      FBpp0072368
      Conserved Domains (3) summary
      smart00220
      Location:165 → 490
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:577 → 683
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:163 → 490
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

    5. NM_080382.4 → NP_525121.2  Phosphoinositide-dependent kinase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525121.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V164, C7LAC8
      Related
      FBpp0072367
      Conserved Domains (3) summary
      smart00220
      Location:165 → 490
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:577 → 683
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:163 → 490
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

    6. NM_167789.2 → NP_728470.1  Phosphoinositide-dependent kinase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728470.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAC8
      Related
      FBpp0072370
      Conserved Domains (3) summary
      smart00220
      Location:229 → 554
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:641 → 747
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:227 → 554
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

    7. NM_167795.3 → NP_728476.1  Phosphoinositide-dependent kinase 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728476.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V166, H1ZY83
      Related
      FBpp0072371
      Conserved Domains (3) summary
      smart00220
      Location:8 → 274
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:361 → 467
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:1 → 274
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

    8. NM_167794.3 → NP_728475.1  Phosphoinositide-dependent kinase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728475.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V166, H1ZY83
      Related
      FBpp0072373
      Conserved Domains (3) summary
      smart00220
      Location:8 → 274
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:361 → 467
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:1 → 274
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

    9. NM_167793.3 → NP_728474.1  Phosphoinositide-dependent kinase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728474.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V166, H1ZY83
      Related
      FBpp0072372
      Conserved Domains (3) summary
      smart00220
      Location:8 → 274
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01262
      Location:361 → 467
      PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
      cd05581
      Location:1 → 274
      STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V164 A4V164
    A4V166 A4V166
    H5V8B9 H5V8B9
    Q9W0V1.4 Q9W0V1

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