gus gustavus [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: gusprovided by FlyBase
Official Full Name: gustavusprovided by FlyBase
Primary source: FLYBASE:FBgn0026238
Locus tag: Dmel_CG2944
See related: AllianceGenome:FB:FBgn0026238
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A11; CG2944; CG2946; Dmel\CG2944; dmSSB4; Gus; GUS; i25
Summary: Involved in several processes, including dorsal appendage formation; germ cell migration; and regionalization. Located in several cellular components, including cell cortex; perinuclear region of cytoplasm; and pole plasm. Part of Cul5-RING ubiquitin ligase complex and elongin complex. Is expressed in germarium; nurse cell; oocyte; organism; and ovary. Orthologous to human SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1) and SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 41D3-41D3; 2-55 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (5116990..5128321, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (1004495..1015826, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that Fsn- and Gus-containing E3 ligase complexes contribute to establishing a fine-tuned steady state of Vasa ubiquitination that influences the kinetics of posterior Vasa deployment.
Title: Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors.
We report the crystal structure of the B30.2/SPRY domain of a SPRY domain-containing SOCS box (SSB) protein, GUSTAVUS, complexed with a 20 amino acid peptide derived from the RNA helicase VASA, revealing how these domains recognize target proteins.
Title: Structural basis for protein recognition by B30.2/SPRY domains.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c5118216-5117941 mobile_element_type = transposon:INE-1{}2086
Loc: c5119554-5119303 mobile_element_type = transposon:INE-1{}2087
Loc: c5124998-5124882 mobile_element_type = transposon:INE-1{}2917
Loc: c5126720-5125750 mobile_element_type = transposon:1360{}2914
Loc: c5127918-5126750 mobile_element_type = transposon:INE-1{}2912

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in oocyte anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul5-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of elongin complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in pole plasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gustavus

Names: CG2944-PG; CG2944-PH; CG2944-PI; CG2944-PJ; CG2944-PK; CG2944-PL; CG2944-PM; gus-PG; gus-PH; gus-PI; gus-PJ; gus-PK; gus-PL; gus-PM

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

5116990..5128321 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165419.3 → NP_724399.2 gustavus, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724399.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z6D7, A1Z6D9, A1Z6E0, A1Z6E2, F2FB59, Q7JUY1

UniProtKB/TrEMBL

A0A0B4K6X3

Conserved Domains (2) summary

cd03718
Location:234 → 276

SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...

cd12906
Location:56 → 229

SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
NM_001259211.2 → NP_001246140.1 gustavus, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246140.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z6D7, A1Z6D9, A1Z6E0, A1Z6E2, F2FB59, Q7JUY1

UniProtKB/TrEMBL

A0A0B4K6X3

Conserved Domains (2) summary

cd03718
Location:234 → 276

SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...

cd12906
Location:56 → 229

SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
NM_165421.3 → NP_724401.2 gustavus, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724401.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z6D7, A1Z6D9, A1Z6E0, A1Z6E2, F2FB59, Q7JUY1

UniProtKB/TrEMBL

A0A0B4K6X3

Conserved Domains (2) summary

cd03718
Location:234 → 276

SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...

cd12906
Location:56 → 229

SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
NM_165422.3 → NP_724402.2 gustavus, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724402.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z6D7, A1Z6D9, A1Z6E0, A1Z6E2, F2FB59, Q7JUY1

UniProtKB/TrEMBL

A0A0B4K6X3

Conserved Domains (2) summary

cd03718
Location:234 → 276

SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...

cd12906
Location:56 → 229

SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
NM_165418.3 → NP_724398.2 gustavus, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724398.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z6D7, A1Z6D9, A1Z6E0, A1Z6E2, F2FB59, Q7JUY1

UniProtKB/TrEMBL

A0A0B4K6X3

Conserved Domains (2) summary

cd03718
Location:234 → 276

SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...

cd12906
Location:56 → 229

SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
NM_165420.3 → NP_724400.2 gustavus, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724400.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z6D7, A1Z6D9, A1Z6E0, A1Z6E2, F2FB59, Q7JUY1

UniProtKB/TrEMBL

A0A0B4K6X3

Conserved Domains (2) summary

cd03718
Location:234 → 276

SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...

cd12906
Location:56 → 229

SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
NM_136314.4 → NP_610158.3 gustavus, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610158.3

Status: REVIEWED

UniProtKB/Swiss-Prot

A1Z6D7, A1Z6D9, A1Z6E0, A1Z6E2, F2FB59, Q7JUY1

UniProtKB/TrEMBL

A0A0B4K6X3

Conserved Domains (2) summary

cd03718
Location:234 → 276

SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...

cd12906
Location:56 → 229

SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)