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    CG8892 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33719, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8892provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031664
    Locus tag
    Dmel_CG8892
    See related
    AllianceGenome:FB:FBgn0031664
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8892
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human UBXN7 (UBX domain protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8892 in Genome Data Viewer
    Location:
    25B5-25B5; 2-14 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4979513..4981592, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4979513..4981592, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene GDP-mannose 4,6-dehydratase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Reticulon-like1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. Beskow A, et al. J Mol Biol, 2009 Dec 11. PMID 19782090
    2. NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and Xenopus laevis models. Singh MD, et al. PLoS Genet, 2020 Feb. PMID 32053595, Free PMC Article
    3. A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wing. Molnar C, et al. Genetics, 2006 Nov. PMID 16980395, Free PMC Article
    4. Proteomic Analysis of the Ubiquitin Landscape in the Drosophila Embryonic Nervous System and the Adult Photoreceptor Cells. Ramirez J, et al. PLoS One, 2015. PMID 26460970, Free PMC Article
    5. In vivo profiling of the Zucchini proximal proteome in the Drosophila ovary. Nguyen TTM, et al. Development, 2023 Feb 15. PMID 36762624

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8892-PB
    CG8892-PC
    CG8892-PD
    CG8892-PE
    UBX domain 7 like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4979513..4981592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164608.3 → NP_723036.1  uncharacterized protein Dmel_CG8892, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723036.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV52, Q7K4I5
      Related
      FBpp0078681
      Conserved Domains (3) summary
      cd02958
      Location:183 → 294
      UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
      pfam14555
      Location:9 → 46
      UBA_4; UBA-like domain
      cl00155
      Location:412 → 488
      UBQ; Ubiquitin-like proteins

    2. NM_001273135.1 → NP_001260064.1  uncharacterized protein Dmel_CG8892, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260064.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV52, Q7K4I5
      Conserved Domains (3) summary
      cd02958
      Location:183 → 294
      UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
      pfam14555
      Location:9 → 46
      UBA_4; UBA-like domain
      cl00155
      Location:412 → 488
      UBQ; Ubiquitin-like proteins

    3. NM_135047.4 → NP_608891.1  uncharacterized protein Dmel_CG8892, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608891.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV52, Q7K4I5
      Conserved Domains (3) summary
      cd02958
      Location:183 → 294
      UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
      pfam14555
      Location:9 → 46
      UBA_4; UBA-like domain
      cl00155
      Location:412 → 488
      UBQ; Ubiquitin-like proteins

    4. NM_164607.3 → NP_723035.1  uncharacterized protein Dmel_CG8892, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723035.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV52, Q7K4I5
      Related
      FBpp0078682
      Conserved Domains (3) summary
      cd02958
      Location:183 → 294
      UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
      pfam14555
      Location:9 → 46
      UBA_4; UBA-like domain
      cl00155
      Location:412 → 488
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K4I5 Q7K4I5

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