Abd-B Abdominal B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Abd-Bprovided by FlyBase
Official Full Name: Abdominal Bprovided by FlyBase
Primary source: FLYBASE:FBgn0000015
Locus tag: Dmel_CG11648
See related: AllianceGenome:FB:FBgn0000015
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 9; Abd B; abd-B; Abd-b; ABD-B; Abd0B; abdB; Abdb; AbdB; ABDB; AbdB(CA)[[26]]; AbdB-I; AbdB-II; AbdBm; Adb-B; AdbB; bex; BX-C; CG10291; CG11648; DmAbdB; Dmel\CG11648; Droabdb; DROABDB; FAB; Fab-6; Fab-7; Fab-8; Fab6; Fab7; iab; IAB 5; iab-5; iab-6; iab-7; Iab-7; iab-8; iab5; IAB5; iab6; iab7; IAB7; iab8; IAB8; iab8.9; iab8/9; iab9; l(3)89Ed; Mc; Mcp; MCP; pH189; Sab; Tab; tuh-3; twig; Uab-5[Sab]
Summary: Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including genital disc development; male pigmentation; and reproductive structure development. Located in nucleus and polytene chromosome band. Is expressed in several structures, including adult posterior abdominal ganglion neurons; anterior-posterior subdivision of organism; epithelium; genital disc; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in congenital vertical talus and radioulnar synostosis. Orthologous to several human genes including HOXA10 (homeobox A10) and HOXC10 (homeobox C10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 89E4-89E5; 3-59 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (16927212..16972236, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (12752932..12797958, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Boundary bypass activity in the abdominal-B region of the Drosophila bithorax complex is position dependent and regulated.
Title: Boundary bypass activity in the abdominal-B region of the Drosophila bithorax complex is position dependent and regulated.
The Drosophila Fab-7 boundary modulates Abd-B gene activity by guiding an inversion of collinear chromatin organization and alternate promoter use.
Title: The Drosophila Fab-7 boundary modulates Abd-B gene activity by guiding an inversion of collinear chromatin organization and alternate promoter use.
Redundant enhancers in the iab-5 domain cooperatively activate Abd-B in the A5 and A6 abdominal segments of Drosophila.
Title: Redundant enhancers in the iab-5 domain cooperatively activate Abd-B in the A5 and A6 abdominal segments of Drosophila.
The capacity of Abdominal-B to use the sex-specific isoform of Dsx as a cofactor underlines the possibility that these two classes of protein are capable of cooperating in selection and regulation of target genes in a tissue- and sex-specific manner
Title: The Hox gene Abdominal-B uses Doublesex(F) as a cofactor to promote neuroblast apoptosis in the Drosophila central nervous system.
complete reconstitution of bypass and blocking functions
Title: Complete reconstitution of bypass and blocking functions in a minimal artificial Fab-7 insulator from Drosophila bithorax complex.
Data report that the repression of Abd-B, in cyst stem cells (CySCs) is essential for the homeostasis and cell identity maintenance in the adult Drosophila testis. Derepression of Abd-B in CySCs disrupts the proper self-renewal of both germline stem cells (GSCs) and CySCs, and leads to an excessive expansion of early stage somatic cells, which originate from both lineages.
Title: Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis.
iab-7 polycomb response element (PRE) functions as a component of the Fab-7 boundary. The boundary activity of the iab-7 PRE sequence depends upon a complex called the LBC, LBC is a multiprotein complex that contains at least three distinct DNA binding proteins, the GAGA factor (GAF), Clamp, and Mod(mdg4).
Title: The bithorax complex iab-7 Polycomb response element has a novel role in the functioning of the Fab-7 chromatin boundary.
analysis of blocking and bypass activities of the Fab-8 boundary in the Drosophila bithorax complex
Title: Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex.
Abd-B is required in neurons during development for females to become highly receptive to male courtship. Abd-B neurons control pausing, a key aspect of female sexual receptivity, in response to male courtship.
Title: Abdominal-B neurons control Drosophila virgin female receptivity.
We also observed that these functions of abd-A are required in its exclusive as well as the coexpression domain with that of Abd-B
Title: Role of abd-A and Abd-B in development of abdominal epithelia breaks posterior prevalence rule.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in determination of genital disc primordium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in external genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in genital disc anterior/posterior pattern formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in genital disc sexually dimorphic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	TAS Traceable Author Statement more info	PubMed
involved_in gonadal mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived female genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male pigmentation	IDA Inferred from Direct Assay more info	PubMed
involved_in midgut development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cardioblast cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of female receptivity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of salivary gland boundary specification	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of striated muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroendocrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process involved in morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in segment specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in specification of segmental identity, abdomen	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spiracle morphogenesis, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome band	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: abdominal B

Names: Abd-B-PA; Abd-B-PB; Abd-B-PC; Abd-B-PD; Abd-B-PE; Abd-B-PF; Abd-B-PG; Abd-B-PH; Abd-B-PI; Abd-B-PJ; Abdominal-B; AbdominalB; CG11648-PA; CG11648-PB; CG11648-PC; CG11648-PD; CG11648-PE; CG11648-PF; CG11648-PG; CG11648-PH; CG11648-PI; CG11648-PJ; abdominal-A; corset; infra-abdominal 5; infra-abdominal 6; infra-abdominal 7; infra-abdominal 8; infra-abdominal 9; infraabdominal; infraabdominal-8.9; male chauvinist pigmentation; microcephalus; miscadastral pigmentation; superabdominal; transabdominal

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

16927212..16972236 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206498.2 → NP_996220.1 abdominal B, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996220.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V304

Conserved Domains (1) summary

pfam00046
Location:167 → 220

Homeobox; Homeobox domain
NM_001316545.1 → NP_001303474.1 abdominal B, isoform I [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A4V304

Conserved Domains (1) summary

pfam00046
Location:167 → 220

Homeobox; Homeobox domain
NM_001316543.1 → NP_001303472.1 abdominal B, isoform H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P09087, Q9VEQ8, Q9VEQ9

UniProtKB/TrEMBL

A0A126GUV3

Conserved Domains (1) summary

pfam00046
Location:390 → 443

Homeobox; Homeobox domain
NM_001316542.1 → NP_001303471.1 abdominal B, isoform J [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A4V304

Conserved Domains (1) summary

pfam00046
Location:167 → 220

Homeobox; Homeobox domain
NM_169735.2 → NP_732180.1 abdominal B, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732180.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V304

Related

FBpp0082823

Conserved Domains (1) summary

pfam00046
Location:167 → 220

Homeobox; Homeobox domain
NM_142320.2 → NP_650577.1 abdominal B, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650577.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V304

Related

FBpp0082824

Conserved Domains (1) summary

pfam00046
Location:167 → 220

Homeobox; Homeobox domain
NM_169736.2 → NP_732181.1 abdominal B, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732181.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V304

Related

FBpp0082825

Conserved Domains (1) summary

pfam00046
Location:167 → 220

Homeobox; Homeobox domain
NM_001275719.2 → NP_001262648.1 abdominal B, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262648.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGT1

Conserved Domains (1) summary

pfam00046
Location:167 → 220

Homeobox; Homeobox domain
NM_001316544.1 → NP_001303473.1 abdominal B, isoform G [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A126GUV9

Conserved Domains (1) summary

pfam00046
Location:167 → 220

Homeobox; Homeobox domain
NM_080157.3 → NP_524896.2 abdominal B, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524896.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P09087, Q9VEQ8, Q9VEQ9

UniProtKB/TrEMBL

A0A126GUV3

Related

FBpp0082826

Conserved Domains (1) summary

pfam00046
Location:390 → 443

Homeobox; Homeobox domain

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4KGT1		A0A0B4KGT1
A0A126GUV3		A0A126GUV3
A0A126GUV9		A0A126GUV9
A4V304		A4V304
P09087.3		P09087
Q86P38		Q86P38
Q9VEQ7		Q9VEQ7
V9H1H6		V9H1H6