FMRFa FMRFamide [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: FMRFaprovided by FlyBase
Official Full Name: FMRFamideprovided by FlyBase
Primary source: FLYBASE:FBgn0000715
Locus tag: Dmel_CG2346
See related: AllianceGenome:FB:FBgn0000715
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2346; dFmrf; dFMRF; dFmrfa; dFMRFa; dFMRFa-1; dFMRFa-2; dFMRFa-3; dFMRFa-4; dFMRFa-5; dFMRFa-6; dFMRFa-7; dFMRFa-8; Dmel\CG2346; DPKQDFMRF-amide; DPKQDFMRFamide; Drm-FMRF-1; Drm-FMRF-2; Drm-FMRF-3; Drm-FMRF-4; Drm-FMRF-5; Drm-FMRFa1; Drm-FMRFa2; Drm-FMRFa3; Drm-FMRFa4; fmrf; Fmrf; FmrF; FMRF; FMRF Famide; FMRFa-1; FMRFa-2; FMRFa-3; FMRFa-4; FMRFa-5; FMRFa-6; FMRFa-7; FMRFa-8; FMRFa-like
Summary: Enables neuropeptide receptor binding activity and receptor ligand activity. Involved in several processes, including negative regulation of heart rate; neuropeptide signaling pathway; and positive regulation of neuromuscular synaptic transmission. Located in extracellular space. Is expressed in several structures, including adult head; brain; central nervous system; neurons; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 46C4-46C4; 2-61 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9906294..9910457)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5793799..5797962)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse.
Title: Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse.
Genetic and cellular assays demonstrated that FMRFaR stimulates intracellular calcium signaling through the IP3R and helps maintain neuronal excitability in a subset of dopaminergic neurons for positive modulation of flight bout durations.
Title: FMRFa receptor stimulated Ca2+ signals alter the activity of flight modulating central dopaminergic neurons in Drosophila melanogaster.
Animals mutant for either FMRFamide or for the FMRFamide receptor (FR) have a reduced recovery sleep in response to heat stress.
Title: FMRFamide signaling promotes stress-induced sleep in Drosophila.
DPKQDFMRFamide induces contractions via a G-protein coupled FMRFamide receptor in muscle cells but does not appear to act via cAMP, cGMP, CaMKII or arachidonic acid.
Title: Mode of action of a Drosophila FMRFamide in inducing muscle contraction.
Klu is expressed specifically in the postmitotic Ap4/FMRFa neuron, promoting its differentiation through the initiation of BMP signaling
Title: Klumpfuss controls FMRFamide expression by enabling BMP signaling within the NB5-6 lineage.
DPKQDFMRFamide modulates both synaptic function and behavior through coincident detection mediated by FMRF receptor and dromyosuppressin receptor-2.
Title: Peptide-induced modulation of synaptic transmission and escape response in Drosophila requires two G-protein-coupled receptors.
hybridization in situ shows a lack of co-localization of mRNAs for the circadian neuropeptide PDF and FMRFamide in brains of the flies Musca domestica and Drosophila melanogaster
Title: Double-labelled in situ hybridization reveals the lack of co-localization of mRNAs for the circadian neuropeptide PDF and FMRFamide in brains of the flies Musca domestica and Drosophila melanogaster.
Supplying FMRFa in neurosecretory cells partially rescues the wit lethal phenotype.
Title: Retrograde Gbb signaling through the Bmp type 2 receptor wishful thinking regulates systemic FMRFa expression in Drosophila.
Here, we review FMRFamide-containing peptides encoded by the D. melanogaster FMRFamide gene in order to review the data on the expression, regulation, and activity of these peptides as well as acknowledge endeavors required to elucidate FaRP signaling.
Title: Drosophila melanogaster FMRFamide-containing peptides: redundant or diverse functions?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables neuropeptide receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral defense response	IDA Inferred from Direct Assay more info	PubMed
involved_in larval locomotory behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of heart contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of heart rate	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuromuscular synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of striated muscle contraction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IC Inferred by Curator more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: FMRFamide

Names: CG2346-PA; DPKQDFMRFamide; Drm-FMRFamide-1; Drm-FMRFamide-2; Drm-FMRFamide-3; Drm-FMRFamide-4; Drm-FMRFamide-5; FMRF amide homologue precursor; FMRF-amide; FMRFa-PA; FMRFamide prohormone; FMRFamide-related; FRMFamide; SDNFMRFamide; TPAEDFMRFamide; amino acid amidated neuropeptide; dFMRFamide