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    plu plutonium [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44848, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pluprovided by FlyBase
    Official Full Name
    plutoniumprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003114
    Locus tag
    Dmel_CG9183
    See related
    AllianceGenome:FB:FBgn0003114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9183; Dmel\CG9183; Plu; PLU
    Summary
    Involved in egg activation and negative regulation of DNA replication. Part of serine/threonine protein kinase complex. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See plu in Genome Data Viewer
    Location:
    56F11-56F11; 2-90 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20262958..20263684, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16150463..16151189, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Hormone-sensitive lipase Neighboring gene Proliferating cell nuclear antigen Neighboring gene antisense RNA:CR43812 Neighboring gene Ribosomal protein S18 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila plutonium and pan gu genes regulate entry into S phase at fertilization. Shamanski FL, et al. Cell, 1991 Sep 20. PMID 1913810
    2. Rapid DNA Synthesis During Early Drosophila Embryogenesis Is Sensitive to Maternal Humpty Dumpty Protein Function. Lesly S, et al. Genetics, 2017 Nov. PMID 28942426, Free PMC Article
    3. Premature translation of the Drosophila zygotic genome activator Zelda is not sufficient to precociously activate gene expression. Larson ED, et al. G3 (Bethesda), 2022 Aug 25. PMID 35876878, Free PMC Article
    4. The inhibitor of DNA replication encoded by the Drosophila gene plutonium is a small, ankyrin repeat protein. Axton JM, et al. EMBO J, 1994 Jan 15. PMID 8313891, Free PMC Article
    5. Mechanisms restricting DNA replication to once per cell cycle: MCMS, pre-replicative complexes and kinases. Romanowski P, et al. Trends Cell Biol, 1996 May. PMID 15157470

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. component of novel protein kinase complex that specifically regulates S-M cell cycles
      Title: The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in egg activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein kinase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of serine/threonine protein kinase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plutonium
    Names
    CG9183-PA
    plu-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20262958..20263684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057335.3 → NP_476683.1  plutonium [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476683.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42570, Q9V910
      UniProtKB/TrEMBL
      Q868J0
      Related
      FBpp0085618
      Conserved Domains (3) summary
      cd00204
      Location:32 → 124
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13637
      Location:40 → 93
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:39 → 70
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42570.1 P42570
    Q868J0 Q868J0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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