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    rod rough deal [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43719, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rodprovided by FlyBase
    Official Full Name
    rough dealprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003268
    Locus tag
    Dmel_CG1569
    See related
    AllianceGenome:FB:FBgn0003268
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1569; Dmel\CG1569; EP3408; pNB20A; Rod; ROD; Rod1
    Summary
    Enables small GTPase binding activity. Involved in several processes, including mitotic sister chromatid segregation; mitotic spindle assembly checkpoint signaling; and protein localization to kinetochore. Located in Golgi apparatus; kinetochore; and spindle. Part of RZZ complex. Is expressed in larval brain and spermatocyte. Orthologous to human KNTC1 (kinetochore associated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rod in Genome Data Viewer
    Location:
    100C6-100C7; 3-102 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31580951..31588244)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27406673..27413966)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Coat Protein (coatomer) gamma Neighboring gene pygopus Neighboring gene antisense RNA:CR45190 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. rough deal: a gene required for proper mitotic segregation in Drosophila. Karess RE, et al. J Cell Biol, 1989 Dec. PMID 2512302, Free PMC Article
    2. Waiting for anaphase: Mad2 and the spindle assembly checkpoint. Shah JV, et al. Cell, 2000 Dec 22. PMID 11163175
    3. The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants. Savoian MS, et al. Nat Cell Biol, 2000 Dec. PMID 11146661
    4. The rough deal protein is a new kinetochore component required for accurate chromosome segregation in Drosophila. Scaërou F, et al. J Cell Sci, 1999 Nov. PMID 10523511
    5. Conserved organization of centromeric chromatin in flies and humans. Blower MD, et al. Dev Cell, 2002 Mar. PMID 11879637, Free PMC Article

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in the Drosophila rough deal gene affecting RZZ kinetochore function.
      Title: Mutations in the Drosophila rough deal gene affecting RZZ kinetochore function.
    2. A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.
      Title: A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment.
    3. Zwilch localizes to kinetochores and kinetochore microtubules in a manner identical to ZW10 and ROD.
      Title: Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.
    4. Rod/Zw10 thus contributes to checkpoint activation by promoting Mad2 recruitment and to checkpoint inactivation by recruiting dynein/dynactin that subsequently removes Mad2 from attached kinetochores.
      Title: Recruitment of Mad2 to the kinetochore requires the Rod/Zw10 complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to kinetochore involved in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RZZ complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RZZ complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RZZ complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in acroblast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rough deal
    Names
    CG1569-PA
    rod-PA
    roughdeal

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31580951..31588244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057357.3 → NP_476705.1  rough deal [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476705.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96695, Q9V9W7
      Related
      FBpp0085156
      Conserved Domains (1) summary
      pfam10493
      Location:1544 → 2082
      Rod_C; Rough deal protein C-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96695 O96695
    Q9V9W7 Q9V9W7

    Gene LinkOut

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