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    LysB Lysozyme B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38125, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LysBprovided by FlyBase
    Official Full Name
    Lysozyme Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004425
    Locus tag
    Dmel_CG1179
    See related
    AllianceGenome:FB:FBgn0004425
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1179; Dmel\CG1179; Lys B; lysB
    Summary
    Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular space. Is expressed in adult midgut and embryonic/larval midgut. Orthologous to human LYZ (lysozyme). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See LysB in Genome Data Viewer
    Location:
    61F3-61F3; 3-0 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1207371..1207981)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1207371..1207981)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene multiple wing hairs Neighboring gene meep Neighboring gene uncharacterized protein Neighboring gene Lysozyme C Neighboring gene Lysozyme D Neighboring gene Lysozyme E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Commensal Gut Bacteria Buffer the Impact of Host Genetic Variants on Drosophila Developmental Traits under Nutritional Stress. Ma D, et al. iScience, 2019 Sep 27. PMID 31422284, Free PMC Article
    2. The lysozyme locus in Drosophila melanogaster: an expanded gene family adapted for expression in the digestive tract. Daffre S, et al. Mol Gen Genet, 1994 Jan. PMID 8159165
    3. Insect lysozymes. Hultmark D. EXS, 1996. PMID 8765296
    4. Molecular adaptation of Drosophila melanogaster lysozymes to a digestive function. Regel R, et al. Insect Biochem Mol Biol, 1998 May-Jun. PMID 9692234
    5. Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI. Sala A, et al. EMBO J, 2011 May 4. PMID 21448136, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysozyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysozyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lysozyme B
    Names
    CG1179-PA
    CG1179-PB
    LysB-PA
    LysB-PB
    lyzozyme B
    NP_001261245.1
    NP_523882.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1207371..1207981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274316.1 → NP_001261245.1  lysozyme B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261245.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P37158, Q08694, Q9W0J8
      UniProtKB/TrEMBL
      D3PFG8
      Conserved Domains (1) summary
      pfam00062
      Location:19 → 139
      Lys; C-type lysozyme/alpha-lactalbumin family

    2. NM_079158.3 → NP_523882.1  lysozyme B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523882.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P37158, Q08694, Q9W0J8
      UniProtKB/TrEMBL
      D3PFG8
      Related
      FBpp0072524
      Conserved Domains (1) summary
      pfam00062
      Location:19 → 139
      Lys; C-type lysozyme/alpha-lactalbumin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3PFG8 D3PFG8
    Q08694.2 Q08694

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