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    PolA2 DNA polymerase alpha subunit 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43278, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PolA2provided by FlyBase
    Official Full Name
    DNA polymerase alpha subunit 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0005696
    Locus tag
    Dmel_CG5923
    See related
    AllianceGenome:FB:FBgn0005696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5923; Dmel\CG5923; Dmpol alpha; DNA pol-73; DNA polalpha; DNA polymerase alpha 73 kD; DNApol-alpha; DNApol-alpha72; DNApol-alpha73; DNApolalpha; Pol; pol alpha; POLA; polalpha; Polalpha; Polalpha 73kDa; Polalpha 73KDa; Polalpha73
    Summary
    Predicted to enable DNA binding activity. Involved in DNA-templated DNA replication. Part of alpha DNA polymerase:primase complex. Is expressed in female pronucleus and male pronucleus. Orthologous to human POLA2 (DNA polymerase alpha 2, accessory subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PolA2 in Genome Data Viewer
    Location:
    97E10-97E10; 3-92 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27239163..27241228)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23064885..23066950)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation and dephosphorylation of the B subunit of DNA polymerase alpha-primase complex in the early embryogenesis of Drosophila. Kuroda K, et al. Biochem Biophys Res Commun, 1999 Jan 19. PMID 9918845
    2. Cloning of the gene for the 73 kD subunit of the DNA polymerase alpha primase of Drosophila melanogaster. Cotterill S, et al. Nucleic Acids Res, 1992 Aug 25. PMID 1508723, Free PMC Article
    3. A 130 kDa polypeptide immunologically related to the 180 kDa catalytic subunit of DNA polymerase alpha-primase complex is detected in early embryos of Drosophila. Kuroda K, et al. J Biochem, 1995 Apr. PMID 7592543
    4. A comparison of the fidelity of copying 5-methylcytosine and cytosine at a defined DNA template site. Shen JC, et al. Nucleic Acids Res, 1992 Oct 11. PMID 1383939, Free PMC Article
    5. Specification of regions of DNA replication initiation during embryogenesis in the 65-kilobase DNApolalpha-dE2F locus of Drosophila melanogaster. Sasaki T, et al. Mol Cell Biol, 1999 Jan. PMID 9858578, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha DNA polymerase:primase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of alpha DNA polymerase:primase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase alpha subunit 2
    Names
    B subunit
    CG5923-PC
    DNA polymerase 73K
    DNA polymerase alpha
    DNA polymerase alpha 73,000 alpha subunit
    DNA polymerase alpha 73kD
    DNA polymerase alpha 73kD subunit
    DNA polymerase alpha primase 73 kda subunit
    DNA-polymerase alpha
    DNApol-alpha73
    PolA2-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27239163..27241228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170327.4 → NP_733206.3  DNA polymerase alpha subunit 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733206.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95S59, Q9TXB0, Q9VB62
      UniProtKB/TrEMBL
      T2GG50
      Conserved Domains (2) summary
      pfam04042
      Location:363 → 561
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:18 → 180
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VB62.2 Q9VB62

    Gene LinkOut

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