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    TpnC41C Troponin C at 41C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35473, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TpnC41Cprovided by FlyBase
    Official Full Name
    Troponin C at 41Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013348
    Locus tag
    Dmel_CG2981
    See related
    AllianceGenome:FB:FBgn0013348
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2981; Dmel\CG2981; DmTnC1; DmTpnC41C; DmTpnCIIIa; TnC; Tnc1; TnC1; TnC41C; TNC41C; TPNC; TpnC IIIa; TpnC4; TpnC41; TPnC41C; TpnCIIIa
    Summary
    Predicted to enable calcium ion binding activity and enzyme regulator activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in cytoplasm. Is expressed in adult heart; indirect flight muscle cell; leg; mesothoracic tergotrochanter muscle cell; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TpnC41C in Genome Data Viewer
    Location:
    41D1-41D1; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5065237..5070210, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (952742..957715, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 41a Neighboring gene long non-coding RNA:CR44105 Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neural control and precision of flight muscle activation in Drosophila. Lehmann FO, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2017 Jan. PMID 27942807, Free PMC Article
    2. The roles of troponin C isoforms in the mechanical function of Drosophila indirect flight muscle. Eldred CC, et al. J Muscle Res Cell Motil, 2014 Aug. PMID 25134799, Free PMC Article
    3. Expression of the Troponin C at 41C Gene in Adult Drosophila Tubular Muscles Depends upon Both Positive and Negative Regulatory Inputs. Chechenova MB, et al. PLoS One, 2015. PMID 26641463, Free PMC Article
    4. Functional redundancy and nonredundancy between two Troponin C isoforms in Drosophila adult muscles. Chechenova MB, et al. Mol Biol Cell, 2017 Mar 15. PMID 28077621, Free PMC Article
    5. Drosophila melanogaster genes encoding three troponin-C isoforms and a calmodulin-related protein. Fyrberg C, et al. Biochem Genet, 1994 Apr. PMID 7980384

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TnC1 was found to be not essential for the mechanical function of indirect flight muscle.
      Title: The roles of troponin C isoforms in the mechanical function of Drosophila indirect flight muscle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    troponin C at 41C
    Names
    CG2981-PA
    CG2981-PB
    TpnC41C-PA
    TpnC41C-PB
    TroponinC at 41C
    troponin C
    troponin-C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5065237..5070210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259210.1 → NP_001246139.1  troponin C at 41C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246139.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P47947, Q9V9E1
      UniProtKB/TrEMBL
      A0A0B4K6P6
      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 150
      PTZ00184; calmodulin; Provisional

    2. NM_078895.4 → NP_523619.2  troponin C at 41C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523619.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P47947, Q9V9E1
      UniProtKB/TrEMBL
      A0A0B4K6P6
      Related
      FBpp0085438
      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 150
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6P6 A0A0B4K6P6
    P47947.2 P47947

    Gene LinkOut

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