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    Bro Brother [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38202, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Broprovided by FlyBase
    Official Full Name
    Brotherprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013755
    Locus tag
    Dmel_CG7960
    See related
    AllianceGenome:FB:FBgn0013755
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bro; CG7960; Dmel\CG7960; rpbeta1
    Summary
    Enables transcription coactivator activity. Involved in regulation of hemocyte proliferation. Located in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human CBFB (core-binding factor subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bro in Genome Data Viewer
    Location:
    62A9-62A9; 3-0.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1647869..1648612)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1647869..1648612)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Coat Protein (coatomer) alpha Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45815 Neighboring gene uncharacterized protein Neighboring gene Vesicle trafficking 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Function of CBFbeta/Bro proteins. Adya N, et al. Semin Cell Dev Biol, 2000 Oct. PMID 11105900
    2. Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt. Golling G, et al. Mol Cell Biol, 1996 Mar. PMID 8622696, Free PMC Article
    3. Runt domain partner proteins enhance DNA binding and transcriptional repression in cultured Drosophila cells. Fujioka M, et al. Genes Cells, 1996 Aug. PMID 9077443
    4. Direct activation of Sex-lethal transcription by the Drosophila runt protein. Kramer SG, et al. Development, 1999 Jan. PMID 9834198
    5. Differential interactions between Brother proteins and Runt domain proteins in the Drosophila embryo and eye. Li LH, et al. Development, 1999 Aug. PMID 10393111

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in compound eye development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of hemocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core-binding factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    brother
    Names
    Bro-PA
    CG7960-PA
    beta for runt and OTHERs
    runt domain partner beta1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1647869..1648612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057718.3 → NP_477066.2  brother [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477066.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24039, Q9W0B5
      UniProtKB/TrEMBL
      B5RJ16
      Related
      FBpp0072643
      Conserved Domains (1) summary
      pfam02312
      Location:37 → 192
      CBF_beta; Core binding factor beta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24039.2 Q24039
    Q2XYL8 Q2XYL8

    Gene LinkOut

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