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    Ssb-c31a Single stranded-binding protein c31A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34120, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ssb-c31aprovided by FlyBase
    Official Full Name
    Single stranded-binding protein c31Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015299
    Locus tag
    Dmel_CG8396
    See related
    AllianceGenome:FB:FBgn0015299
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c31A; C31A; CG8396; Dmel\CG8396; p11; PC4-like; Ssb-C31a
    Summary
    Enables single-stranded DNA binding activity. Involved in negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including central brain primordium; ganglia; germline cell; gonad; and ventral nerve cord primordium. Orthologous to human SUB1 (SUB1 regulator of transcription). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ssb-c31a in Genome Data Viewer
    Location:
    28F3-28F3; 2-30 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8211347..8211938)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8211347..8211938)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44121 Neighboring gene uncharacterized protein Neighboring gene Suppressor of variegation 205 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization and cloning of p11, a transrepressor of Drosophila melanogaster retrotransposon 1731. Lacoste J, et al. Nucleic Acids Res, 1995 Dec 25. PMID 8559667, Free PMC Article
    2. Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation. Gelbart ME, et al. Nat Struct Mol Biol, 2009 Aug. PMID 19648925, Free PMC Article
    3. Sox21b underlies the rapid diversification of a novel male genital structure between Drosophila species. Ridgway AM, et al. Curr Biol, 2024 Mar 11. PMID 38309269
    4. TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription. Hsu JY, et al. Genes Dev, 2008 Sep 1. PMID 18703680, Free PMC Article
    5. FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal. Berger C, et al. Cell Rep, 2012 Aug 30. PMID 22884370, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    single stranded-binding protein c31A
    Names
    CG8396-PA
    Ssb-c31a-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8211347..8211938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057788.4 → NP_477136.1  single stranded-binding protein c31A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477136.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24026, Q4V3U5, Q9VLR5
      UniProtKB/TrEMBL
      A0A1B2AJ64
      Related
      FBpp0079211
      Conserved Domains (1) summary
      pfam02229
      Location:55 → 99
      PC4; Transcriptional Coactivator p15 (PC4)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLR5.1 Q9VLR5

    Gene LinkOut

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