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    asRNA:CR11538 antisense RNA:CR11538 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 26067081, updated on 9-Dec-2024

    Summary

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    Official Symbol
    asRNA:CR11538provided by FlyBase
    Official Full Name
    antisense RNA:CR11538provided by FlyBase
    Primary source
    FLYBASE:FBgn0017424
    Locus tag
    Dmel_CR11538
    See related
    AllianceGenome:FB:FBgn0017424
    Gene type
    ncRNA
    RNA name
    antisense_RNA
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-68Ed; CG11538; CR11538; Dmel\CR11538; LncRNA-CR11538
    Summary
    Enables protein sequestering activity and transcription regulator inhibitor activity. Involved in negative regulation of Toll signaling pathway; negative regulation of antimicrobial peptide production; and negative regulation of peptidoglycan recognition protein signaling pathway. Is active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See asRNA:CR11538 in Genome Data Viewer
    Location:
    68F5-68F5; 3-38 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12129103..12131488, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 68b Neighboring gene uncharacterized protein Neighboring gene Larval serum protein 2 Neighboring gene antisense RNA:CR45892 Neighboring gene differentially expressed in FDCP 8 homolog Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NT_037436.4 Chromosome 3L Reference Release 6 plus ISO1 MT Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence, structure and evolution of the ecdysone-inducible Lsp-2 gene of Drosophila melanogaster. Mousseron-Grall S, et al. Eur J Biochem, 1997 Apr 1. PMID 9128741
    2. LncRNA-CR11538 Decoys Dif/Dorsal to Reduce Antimicrobial Peptide Products for Restoring Drosophila Toll Immunity Homeostasis. Zhou H, et al. Int J Mol Sci, 2021 Sep 18. PMID 34576280, Free PMC Article
    3. The identification of regulatory ceRNA network involved in Drosophila Toll immune responses. Huang Y, et al. Dev Comp Immunol, 2024 Feb. PMID 38013113
    4. Relish-facilitated lncRNA-CR11538 suppresses Drosophila Imd immune response and maintains immune homeostasis via decoying Relish away from antimicrobial peptide promoters. Huang Y, et al. Dev Comp Immunol, 2024 Feb. PMID 37956726
    5. Accentuate the negative: proteome comparisons using the negative proteome database. Reiter LT, et al. Fly (Austin), 2007 May-Jun. PMID 18820470

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA-CR11538 Decoys Dif/Dorsal to Reduce Antimicrobial Peptide Products for Restoring Drosophila Toll Immunity Homeostasis.
      Title: LncRNA-CR11538 Decoys Dif/Dorsal to Reduce Antimicrobial Peptide Products for Restoring Drosophila Toll Immunity Homeostasis.
    Submit: New GeneRIF Correction

    General gene information

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    • asRNA:CR11538-RC; Dmel\asRNA:CR11538-RC; CR11538-RC; Dmel\CR11538-RC

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein sequestering activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription regulator inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of Toll signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12129103..12131488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. NR_133226.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases