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    robl roadblock [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36963, updated on 9-Dec-2024

    Summary

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    Official Symbol
    roblprovided by FlyBase
    Official Full Name
    roadblockprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024196
    Locus tag
    Dmel_CG10751
    See related
    AllianceGenome:FB:FBgn0024196
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10751; DLC; Dmel\CG10751; l(2)k10408; LC7; Roadblock; roblk
    Summary
    Enables dynein intermediate chain binding activity. Involved in dendrite morphogenesis; microtubule-based movement; and mushroom body development. Part of axonemal dynein complex and cytoplasmic dynein complex. Orthologous to several human genes including DYNLRB2 (dynein light chain roadblock-type 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See robl in Genome Data Viewer
    Location:
    54B16-54B16; 2-82 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17456472..17457129)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13343977..13344634)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene roadblock similar 54B Neighboring gene uncharacterized protein Neighboring gene Testin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spatial and temporal characteristics of normal and perturbed vesicle transport. Iacobucci GJ, et al. PLoS One, 2014. PMID 24878565, Free PMC Article
    2. Presenilin influences glycogen synthase kinase-3 β (GSK-3β) for kinesin-1 and dynein function during axonal transport. Dolma K, et al. Hum Mol Genet, 2014 Mar 1. PMID 24105467
    3. The crystal structure of dynein intermediate chain-light chain roadblock complex gives new insights into dynein assembly. Hall J, et al. J Biol Chem, 2010 Jul 16. PMID 20472935, Free PMC Article
    4. A mosaic genetic screen for genes necessary for Drosophila mushroom body neuronal morphogenesis. Reuter JE, et al. Development, 2003 Mar. PMID 12571111
    5. Light chain-dependent self-association of dynein intermediate chain. Nyarko A, et al. J Biol Chem, 2011 Jan 14. PMID 20974845, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of axonemal dynein complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic dynein complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    roadblock
    Names
    CG10751-PA
    dynein light chain
    dynein light chain LC7
    dynein, light chain, roadblock-type 2
    robl-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17456472..17457129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079047.4 → NP_523771.1  roadblock [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523771.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMS3
      Related
      FBpp0086076
      Conserved Domains (1) summary
      pfam03259
      Location:4 → 94
      Robl_LC7; Roadblock/LC7 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KMS3 Q7KMS3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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