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    cato cousin of atonal [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    catoprovided by FlyBase
    Official Full Name
    cousin of atonalprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024249
    Locus tag
    Dmel_CG7760
    See related
    AllianceGenome:FB:FBgn0024249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bHLHa12; Cato; CG7760; DATH-B; Dmel\CG7760
    Summary
    Predicted to enable DNA-binding transcription factor activity and E-box binding activity. Involved in sensory organ development. Predicted to be active in nucleus. Is expressed in several structures, including Bolwig organ primordium; antennal primordium; peripheral sensory precursor cell; sense organ; and sensory nervous system primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cato in Genome Data Viewer
    Location:
    53A4-53A4; 2-79 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16277685..16278396, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12165190..12165901, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Kinesin heavy chain Neighboring gene uncharacterized protein Neighboring gene primacord Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary changes in transcription factor coding sequence quantitatively alter sensory organ development and function. Weinberger S, et al. Elife, 2017 Apr 13. PMID 28406397, Free PMC Article
    2. All in the family: proneural bHLH genes and neuronal diversity. Baker NE, et al. Development, 2018 May 2. PMID 29720483, Free PMC Article
    3. cato encodes a basic helix-loop-helix transcription factor implicated in the correct differentiation of Drosophila sense organs. Goulding SE, et al. Dev Biol, 2000 May 1. PMID 10772796
    4. An ancient transcriptional regulatory linkage. Rebeiz M, et al. Dev Biol, 2005 May 15. PMID 15893980
    5. The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis. zur Lage PI, et al. BMC Dev Biol, 2010 Mar 26. PMID 20346138, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables E-box binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cousin of atonal
    Names
    CG7760-PA
    cato-PA
    drosophila atonal homologue

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16277685..16278396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057996.5 → NP_477344.1  cousin of atonal [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477344.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0IGT4, Q9XZC7
      Related
      FBpp0086327
      Conserved Domains (1) summary
      pfam00010
      Location:104 → 155
      HLH; Helix-loop-helix DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0IGT4 Q0IGT4
    Q9XZC7 Q9XZC7

    Gene LinkOut

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