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    PHDP Putative homeodomain protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37788, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PHDPprovided by FlyBase
    Official Full Name
    Putative homeodomain proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025334
    Locus tag
    Dmel_CG11182
    See related
    AllianceGenome:FB:FBgn0025334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-60Ac; CG11182; Dmel\CG11182
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in embryonic brain and larval ventral nerve cord. Human ortholog(s) of this gene implicated in colorectal cancer; congenital central hypoventilation syndrome; congenital fibrosis of the extraocular muscles 2; and neuroblastoma. Orthologous to several human genes including PHOX2B (paired like homeobox 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PHDP in Genome Data Viewer
    Location:
    60A7-60A8; 2-105 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23883136..23884440, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19770659..19771963, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ken and barbie Neighboring gene Transmembrane 4 superfamily Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Decapping protein 1 Neighboring gene DNA ligase 1 Neighboring gene Upf3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Post-transcriptional modulation of cytochrome P450s, Cyp6g1 and Cyp6g2, by miR-310s cluster is associated with DDT-resistant Drosophila melanogaster strain 91-R. Seong KM, et al. Sci Rep, 2020 Sep 1. PMID 32873850, Free PMC Article
    2. The Drosophila melanogaster 60A chromosomal division is extremely dense with functional genes: their sequences, genomic organization, and expression. Lukacsovich T, et al. Genomics, 1999 Apr 1. PMID 10191082
    3. Pax3/7 genes reveal conservation and divergence in the arthropod segmentation hierarchy. Davis GK, et al. Dev Biol, 2005 Sep 1. PMID 16083872
    4. Evolution of homeobox genes: Q50 Paired-like genes founded the Paired class. Galliot B, et al. Dev Genes Evol, 1999 Mar. PMID 10079362
    5. Homeobox gene clusters and the human paralogy map. Popovici C, et al. FEBS Lett, 2001 Mar 2. PMID 11240134

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative homeodomain protein
    Names
    CG11182-PA
    PHDP-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23883136..23884440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079110.3 → NP_523834.1  putative homeodomain protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523834.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0IGW1, Q9W1H7
      Related
      FBpp0072133
      Conserved Domains (1) summary
      pfam00046
      Location:116 → 168
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76136 O76136
    Q9W1H7 Q9W1H7

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