scf supercoiling factor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: scfprovided by FlyBase
Official Full Name: supercoiling factorprovided by FlyBase
Primary source: FLYBASE:FBgn0025682
Locus tag: Dmel_CG9148
See related: AllianceGenome:FB:FBgn0025682
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey14; BEST:CK02682; CG9148; CK02682; DCB-45; Dmel\CG9148; SCF
Summary: Predicted to enable calcium ion binding activity. Involved in DNA topological change; dosage compensation by hyperactivation of X chromosome; and positive regulation of DNA-templated transcription. Located in cytoplasm; nucleus; and polytene chromosome puff. Is expressed in several structures, including circulatory system primordium; embryonic/larval hemocyte; mesoderm; nephrocyte; and visceral mesoderm derivative. Orthologous to several human genes including CALU (calumenin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 61F5-61F5; 3-0 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1298672..1300389)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1298672..1300389)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The SCF(Skp2) complex is necessary to ubiquitinate Double-parked during plasmatocyte cell division, ensuring proper cell cycle progression and the generation of a normal population of this essential blood cell type.
Title: Knockdown of SCF(Skp2) function causes double-parked accumulation in the nucleus and DNA re-replication in Drosophila plasmatocytes.
dRYBP-SCF complex inhibit apoptosis in Drosophila.
Title: A novel dRYBP-SCF complex functions to inhibit apoptosis in Drosophila.
The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4.
Title: The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4.
A 54-AA N-terminal fragment of DCB-45 is involved in the interaction with the peptide binding groove of sDQ2, via a pentadecapeptide with high affinity for sDQ2.
Title: Soluble HLA-DQ2 expressed in S2 cells copurifies with a high affinity insect cell derived protein.
SCF helps to activate the anaphase-promoting complex.
Title: Emi1 proteolysis: how SCF(beta-Trcp1) helps to activate the anaphase-promoting complex.
Mutations in genes coding for components of the SCF pathway such as cul1, UbcD2 and effete enhance the extra division phenotype of Encore
Title: Encore facilitates SCF-Ubiquitin-proteasome-dependent proteolysis during Drosophila oogenesis.
SCF plays a role in transcriptional activation via alteration of chromatin structure and contributes to dosage compensation.
Title: DNA supercoiling factor contributes to dosage compensation in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA topological change	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dosage compensation by hyperactivation of X chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endomembrane system	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: supercoiling factor

Names: CG9148-PA; CG9148-PB; DNA supercoiling factor; scf-PA; scf-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

1298672..1300389

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058044.5 → NP_477392.1 supercoiling factor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477392.1

Status: REVIEWED

UniProtKB/TrEMBL

I1V500, Q8SZK6, Q9W0H8

Related

FBpp0088881

Conserved Domains (3) summary

cd00051
Location:206 → 273

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:170 → 227

EF-hand_7; EF-hand domain pair

cl08302
Location:248 → 306

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_058045.4 → NP_477393.1 supercoiling factor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477393.1

Status: REVIEWED

UniProtKB/TrEMBL

O96051, Q8IRH7

Related

FBpp0088880, FBtr0089941

Conserved Domains (2) summary

pfam13499
Location:33 → 90

EF-hand_7; EF-hand domain pair

cl08302
Location:69 → 136

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...