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    SrpRbeta Signal recognition particle receptor beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47283, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SrpRbetaprovided by FlyBase
    Official Full Name
    Signal recognition particle receptor betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011509
    Locus tag
    Dmel_CG33162
    See related
    AllianceGenome:FB:FBgn0011509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM04779; CG33162; CG5950; Dm SRbeta; Dmel\CG33162; l(3)rK561; l(3)rL537; Q9VSN9; SRbeta; srpRbeta
    Summary
    Predicted to enable signal recognition particle binding activity. Involved in chitin-based larval cuticle pattern formation. Located in endomembrane system. Is expressed in adult head and eye-antennal disc. Orthologous to human SRPRB (SRP receptor subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SrpRbeta in Genome Data Viewer
    Location:
    66D11-66D11; 3-26 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8718949..8720225, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8712049..8713325, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene hairy Neighboring gene long non-coding RNA:CR44526 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Construction and transposition of a 100-kilobase extended P element in Drosophila. Ring BC, et al. Genome Res, 2000 Oct. PMID 11042158, Free PMC Article
    2. Nascent polypeptide-Associated Complex and Signal Recognition Particle have cardiac-specific roles in heart development and remodeling. Schroeder AM, et al. PLoS Genet, 2022 Oct. PMID 36240221, Free PMC Article
    3. Small GTPases and the evolution of the eukaryotic cell. Jékely G. Bioessays, 2003 Nov. PMID 14579253
    4. A genetic screen in Drosophila reveals novel cytoprotective functions of the autophagy-lysosome pathway. Arsham AM, et al. PLoS One, 2009 Jun 29. PMID 19562034, Free PMC Article
    5. Gene amplification as a developmental strategy: isolation of two developmental amplicons in Drosophila. Claycomb JM, et al. Dev Cell, 2004 Jan. PMID 14723854

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables signal recognition particle binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chitin-based larval cuticle pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to ER ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of signal recognition particle receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle receptor beta
    Names
    CG33162-PA
    CG33162-PB
    SrpRbeta-PA
    SrpRbeta-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8718949..8720225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274667.1 → NP_001261596.1  signal recognition particle receptor beta, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261596.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDG2, Q9U4F7, Q9VSN9
      Conserved Domains (2) summary
      cd04105
      Location:49 → 243
      SR_beta; Signal recognition particle receptor, beta subunit (SR-beta), together with SR-alpha, forms the heterodimeric signal recognition particle (SRP)
      pfam09439
      Location:51 → 221
      SRPRB; Signal recognition particle receptor beta subunit

    2. NM_176307.3 → NP_788485.1  signal recognition particle receptor beta, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788485.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IDG2, Q9U4F7, Q9VSN9
      Related
      FBpp0076325
      Conserved Domains (2) summary
      cd04105
      Location:49 → 243
      SR_beta; Signal recognition particle receptor, beta subunit (SR-beta), together with SR-alpha, forms the heterodimeric signal recognition particle (SRP)
      pfam09439
      Location:51 → 221
      SRPRB; Signal recognition particle receptor beta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSN9 Q9VSN9

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